The use of high-density MEAs to probe single cell and network activity electrophysiology of a hiPSC-derived Huntington’s disease model

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In this app note you will learn about:

  • The urgent need for more accurate in vitro HD models and advanced methods to analyse their functional properties
  • How high-density MEAs determine spontaneous activity, synchronous network bursting activity and axonal processes of an isogenic, precision reprogrammed hiPSC-derived HD model
  • How this disease model recapitulated the HD phenotype in vitro, including delayed neuronal network formation, decreased axonal branching and decreased spontaneous activity.

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Asset 1: Developing next-gen in vitro Huntington’s disease assays

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