All 3D Cell Cultures articles
-
ArticleOrgan chips move closer to drug discovery pipelines
From uncovering new drug targets to predicting human toxicity, organ chips are showing what they could bring to drug discovery. Professor Donald Ingber of Harvard University discusses where the technology is heading next.
-
NewsSynthetic organiser cells enhance kidney organoid reproducibility and accuracy
Scientists at the University of Southern California have engineered synthetic organiser cells that produce localised Wnt signals to guide kidney organoid development, yielding more reproducible, physiologically accurate structures and revealing a previously unrecognised developmental axis in the human kidney.
-
NewsInsilico Medicine launches Phase III trial of AI-designed Rentosertib drug
Insilico Medicine has advanced its AI-discovered TNIK inhibitor Rentosertib into a 320-patient Phase III trial for idiopathic pulmonary fibrosis, marking a landmark moment for generative AI drug discovery.
-
NewsAI and lab techniques accelerate tuberculosis drug discovery
Researchers at UMass Amherst have combined high-throughput laboratory screening with an AI neural network to identify compounds capable of breaching the protective outer membrane of Mycobacterium tuberculosis, potentially accelerating the search for new TB therapeutics.
-
NewsFish-inspired sensor detects heartbeat of lab-grown cardiac organoids
A biomechanical well plate inspired by the pressure-sensing lateral line of fish can wirelessly monitor the pulse of multiple lab-grown cardiac organoids simultaneously, offering a scalable new platform for cardiovascular drug testing.
-
InterviewThe global push to reduce animal testing in drug development
Non-animal methods are already used throughout early drug discovery, yet animal testing continues to dominate regulatory safety assessment. Recent initiatives suggest change is coming, but significant scientific and practical challenges remain.
-
NewsCerebral organoids identify Ebola virus persistence in neural tissue
Researchers have used human brain organoids to demonstrate that Ebola virus can replicate in neural tissue for up to 120 days, offering new insights into viral persistence mechanisms in immune-privileged sites and late-stage inflammatory complications in survivors.
-
ArticleCerebral organoids reveal how Ebola virus persists in neural tissue
How does Ebola virus survive long after recovery? A new study using human cerebral organoids explores viral persistence in neural tissue and the growing role of organoid models in drug discovery research.
-
NewsNew framework standardises glioma organoid research for translational studies
A collaborative review published in Neuro-Oncology establishes a unified classification system for glioma organoid models, addressing inconsistent terminology and methodology across the rapidly expanding field.
-
ArticleWhy scaling human-derived models is pharma’s next big challenge
Many drugs still fail after promising preclinical results, raising difficult questions about how disease is modelled in the lab. Researchers are now turning to organoids and iPSC-derived systems to build more predictive models for drug discovery and reduce costly late-stage failures.
-
ArticleWhy targeted therapies are exposing the limits of animal models – and what comes next
Traditional preclinical models are struggling to keep pace with a new generation of targeted therapies. As regulators embrace new approach methodologies (NAMs), vascularised tissue platforms are offering a more human-relevant approach to predicting drug efficacy and safety.
-
NewsHow researchers are recreating the human heart in the lab
Many promising therapies fail because preclinical models do not fully capture the complexity of the human heart. A new review explores how 3D cardiac constructs could improve disease modelling, drug screening and safety assessment.
-
NewsCardiac organoids repair heart attack damage in preclinical study
Researchers have developed a scalable bioreactor-based system to produce cardiac organoids that successfully integrated into damaged heart tissue in porcine models of myocardial infarction, improving cardiac function and reducing scar formation without triggering arrhythmias.
-
NewsOrganoid study reveals valproate’s impact on developing brain
German researchers have used cerebral organoids to investigate how the epilepsy medication valproate interferes with early brain development, identifying significant disruption to the extracellular matrix and neuronal maturation that may explain increased neurodevelopmental risks in exposed foetuses.
-
News3D-printed system doubles growth speed of transplantable gut organoids
A novel 3D-printed confined culture system has enabled researchers to generate larger, more advanced human gastrointestinal organoids in half the time of traditional methods, producing transplantation-ready tissues with self-organised enteric neural networks within 14 days.
-
NewsC-Path launches coalition to advance human-relevant drug discovery
The New Approach Methodologies Developer Coalition brings together technology developers, pharmaceutical companies and regulators in a precompetitive initiative to establish qualification standards for complex in vitro models, microphysiological systems and related human-relevant technologies.
-
NewsOvarian follicles provide new platform for angiogenesis research
A novel microphysiological system using ovarian follicles enables physiologically relevant three-dimensional angiogenesis modelling within 24 hours, offering improved drug screening capabilities that distinguish therapeutic effects from general toxicity.
-
News10x Genomics launches Atera whole-transcriptome spatial biology platform
The new platform enables researchers to analyse gene expression and cellular organisation within intact tissue at single-cell resolution, supporting large-scale studies across fresh-frozen and FFPE samples. Early adopters include leading research institutions and global service providers, with cloud-based analysis tools and direct sample processing services now available.
-
WebinarManufacturing the Future: from N=1 personalised CRISPR therapy to scalable precision genomic medicine
How biotech leaders are turning one-off CRISPR breakthroughs into scalable, regulatory-ready therapies.
-
WebinarWhat it takes to automate high-content imaging at scale
This webinar examines the design trade-offs and technical constraints involved in building a high-throughput robotic imaging pipeline for complex biological workflows.