All Cancer articles – Page 24
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NewsNovel tool to rapidly diagnose sarcoidosis
A highly specific blood test can differentiate between patients with sarcoidosis and other respiratory conditions, like TB or lung cancer.
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NewsPotential for targeted therapies based on the gigaxonin pathway
Researchers have discovered that higher expression of gigaxonin suppresses aggressive growth of human head and neck cancer cells.
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NewsNewly discovered role of AF1q in neuroblastoma
Researchers have identified that AF1q is highly expressed in neuroblastoma, and could be used to destabilise N-Myc.
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ArticleMediating BRAF-mutant melanoma resistance
In this Q&A, esteemed Dr Rhoda Alani discusses the epigenetic landscape of therapy resistant melanomas and elucidates how corin treatment impacts the reprogramming of melanoma cell phenotypes. The findings suggest a new treatment paradigm for melanoma which could also be relevant to targeted therapy resistance mechanisms for other cancer types.
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NewsA promising new treatment strategy for hepatoblastoma
A combination therapy of vincristine, irinotecan and panobinostat, tested in high-risk, relapsed or refractory HB spheroids, decreased tumour marker levels.
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ArticleInsights into cellular therapies for cancer treatment
Many exciting developments are expected to take place in immunotherapy and oncology in the next few years. We had the privilege of discussing the opportunities of various cell therapies with Dr Suresh Nair, Physician in Chief, who elucidates how Lehigh Valley Topper Cancer Institute is directing research towards better treatments, ...
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NewsIdentification of an immune biomarker for liver cancer
New immunotherapies may be developed for patients with HCC associated with steatotic liver disease, with TREM1 suggested as a target.
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ArticleA new genetic biomarker to predict immunotherapy success
Tumours with a greater IGR burden could respond better to immune checkpoint blockades, advancing precise treatments for patients.
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NewsThe implications of EN-1 overexpression in late-stage PDAC
Using tumour organoids, researchers identified that overexpression of Engrailed-1 blocked genes associated with natural cell death.
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Improved CAR T-cell immunotherapy for acute myeloid leukaemia
Researchers have created dual-targeted CARs, which performed better than single-targeted CARs in both in vivo and in vitro experiments.
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NewsNew molecular imaging technique improves breast cancer diagnostics
Low-dose positron emission mammography (PEM) has a high sensitivity for detecting cancer and reduces the likelihood of false positives.
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NewsLung adenocarcinoma: metabolic reprogramming of macrophages
Disrupting the mechanism that EGFR-driven lung adenocarcinoma uses to alter macrophages’ lipid metabolism could inspire new treatments.
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ArticleInvestigating the intratumoural microbiome in young-onset CRC patients
New insights about young-onset CRC tumour-related bacteria could lead to new diagnostic markers and therapeutic targets.
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NewsIntegrin αV and β5 partner to drive cancer cell growth
A novel cellular mechanism has been uncovered with the use of CRISPR gene-tiling technology, which could advance oncologic therapies.
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NewsReducing drug resistance in acute myeloid leukaemia patients
Researchers conducted a proteogenomic characterisation and found that drug exposure changes drug sensitivity.
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NewsOrganoid drug testing predicts bowel cancer treatment response
A new study proves that organoid drug testing is highly accurate at predicting effective treatments and finds a novel therapeutic option.
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ArticleThe great prostate debate: innovations in prostate cancer screening
While blood tests measuring prostate-specific antigen (PSA) levels have been a primary screening tool, their limitations in specificity have led to challenges such as overdiagnosis and overtreatment. Cleveland Diagnostics is pioneering an alternative approach with the IsoPSA test, focusing on assessing the structure of the PSA protein rather than its ...
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NewsHow the DA subtype of Wilms tumour resists chemotherapy
Researchers suggest that DA histology slowly emerges by accumulating burdens of DNA damage and copy number aberrations.
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WhitepaperApplication Note: Understanding The Multiplex Imaging Landscape
Learn about the different types of multiplexed imaging available, as well as their applications, benefits and disadvantages.
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NewsAugmenting cancer immunogenicity through MHC class I
A novel technology can reduce tumour sizes significantly and improve treatment efficacy when used with existing immunotherapy.