Read this guide about nanoDSF for high-resolution measurements of thermal stability parameters, common CQAs for biologics developability assessment.
Nano-differential scanning fluorimetry (nanoDSF) is a tool of choice to measure thermal stability, which is one of the most common critical quality attribute (CQA) for biologic candidates.
Read this mini-guide to learn:
- How nanoDSF uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton
- Why high-resolution unfolding data is critical to obtain stability information about mAbs
- What some real-life examples of nanoDSF data look like.
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Asset 3: Screening biologic candidates with nanoDSF
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