This eBook describes different types of assays used to evaluate PARP activity and screening for specific inhibitors.
PARP family member proteins are involved in a wide range of biological functions: repair of DNA damage, genome stability, chromatin remodeling, mitotic spindle assembly, regulation of RNA turnover and of gene expression and DNA methylation. Specifically targeting their functions appears promising in certain therapeutic areas such as cancer. This ebook describes different types of assays used to evaluate PARP activity and screening for specific inhibitors.
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