Drug Target Review Upstream Bioprocessing ebook 2021
In this ebook, find an article on 3D tissue cultures from biopsy samples to evaluate the preservation of tissue-typical protein expressions as well as a piece on a new process analytical technology (PAT) system to assess N-glycosylation during upstream cell culture bioprocessing.
Three-dimensional (3D) biopsy culture models could save the drug discovery industry time and money. Johanna Niklander, University of Helsinki and Medical University of Graz, and Dr Beate Rinner, Medical University of Graz, outline a recent study they took part in, investigating long-term 3D tissue cultures from human biopsy samples to evaluate the preservation of tissue-typical protein expressions.
In another article, Dr Shishir Chundawat and Aron Gyorgypal from Rutgers University, US, explain how they developed a new PAT system for the automated monitoring of antibody N-glycosylation, to ensure the safety of biologics early in their development.
Included in this ebook:
- Human biopsies in nanofibrillar cellulose hydrogel – a novel method for long-term tissue culture
Johanna Niklander, University of Helsinki and Medical University of Graz
Dr Beate Rinner, Medical University of Graz
- Ensuring the safety and efficacy of biologics products
Dr Shishir Chundawat and Aron Gyorgypal, Rutgers University