Optimizing antibody leads in early drug discovery with key developability insights
Supported by:
30 July 2025
9:00am
Shares
- Like
- Digg
- Del
- Tumblr
- VKontakte
- Buffer
- Love This
- Odnoklassniki
- Meneame
- Blogger
- Amazon
- Yahoo Mail
- Gmail
- AOL
- Newsvine
- HackerNews
- Evernote
- MySpace
- Mail.ru
- Viadeo
- Line
- Comments
- Yummly
- SMS
- Viber
- Telegram
- Subscribe
- Skype
- Facebook Messenger
- Kakao
- LiveJournal
- Yammer
- Edgar
- Fintel
- Mix
- Instapaper
- Copy Link
Stop costly biologic failures. This masterclass reveals high-throughput strategies to optimize antibody leads upfront.
Are your promising biologic leads failing in development due to hidden issues like poor stability, aggregation, or low PK? This webinar will equip you with practical, high-throughput strategies to identify and mitigate critical risks early. This means you’ll save significant time, resources, and valuable material before your molecules ever reach costly CMC stages.
What you’ll learn:
- Assess key developability risks (PK, stability, manufacturability) using less than 1 mg of material per assay.
- Explore sensitive, high-throughput assays like AC-SINS, DNA/Insulin ELISA, FcRn affinity, and serum stability for rapid antibody optimization.
- Discover how to combine in silico modeling and in vitro testing to predict CMC risks much earlier in the discovery stage.
- Tailor micro-developability strategies for complex and novel biologic formats, including Fc-lacking biologics.
- Get your questions answered live by Dr. Lei Guo during the interactive Q&A session.
Register now to secure your place >>>
Meet the expert:
Join Dr. Lei Guo, Director of CRO Services at WuXi Biologics, for this exclusive session. With over 14 years of hands-on experience, she’ll reveal how to effectively integrate in silico modeling with cutting-edge in vitro assays for rapid, early lead optimization. Mark your calendar for Wednesday, July 30th, 2025, at 10:00 AM BST.
CASE STUDIES
Dive into practical examples that demonstrate how to:
- Identify CDR hotspots, post-translational modification risks, and aggregation scores using advanced in silico tools.
- Evaluate self-association tendencies with AC-SINS and HIC.
- Assess non-specific binding via BVP/DNA/Insulin ELISA, clearance through FcRn affinity, and half-life using serum stability assays.
- Perform stress testing under low pH, thermal (40°C), and freeze/thaw conditions.
- Troubleshoot charged variants with CIEF-MS.
- Optimize antibody candidates to improve expression, reduce degradation and aggregation, enhance thermal stability, and extend half-life.
Don’t miss this opportunity to transform your biologics discovery workflow. Register now to secure your place!
SPEAKER
Lei Guo, Ph.D. – Director of CRO Services
Dr. Lei Guo leads the Protein Analytical Chemistry group in WuXi Biologics CRO Services Department. Her team specializes in comprehensive analytical testing of monoclonal antibodies, bispecific antibodies, ADCs, and fusion proteins in drug discovery and optimization stages, employing Mass Spectrometry and physicochemical and biophysical analyses. With over 14 years of experience in bioanalysis, Dr. Guo has held diverse roles at Pfizer, Sanofi, and MSD, contributing to target discovery, drug development, and CMC-stage analysis.
FAQs
Is the webinar free?
Yes – there is no charge to watch the webinar, either live or on-demand.
When will the webinar take place?
The webinar will take place live on 30 July 10:00 AM BST.
I’m busy. Can I watch it later?
The webinar will become available to watch on-demand shortly after the live webinar takes place.
What are the benefits of attending live?
During the live webinar, you’ll be able to ask the speakers your questions, which will then be answered during the live Q&A session towards the end of the webinar.
How long will the webinar be?
This webinar will last for up to one hour.
What do I need to watch this webinar?
All you need is a computer with an internet connection. Be sure to use headphones if in an office environment.
Do I receive a certificate?
Yes, you will receive a certificate if you attend the webinar live. The certificate will be sent with your on-demand video link.
