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Webinar

Overcoming Affinity and Expression Bottlenecks in TCR Discovery

22 October 2025

3:00pm

Join this expert-led webinar to learn how to break through common bottlenecks in TCR discovery with practical strategies that help teams move faster and smarter.

T-cell receptor–T-cell engagers (TCR-TCEs) are gaining momentum, but technical roadblocks often slow discovery programs. Struggling with low-affinity TCRs or poor yields? Learn scalable workflows that can boost expression, improve binding, and accelerate your pipeline.

As pressure mounts to improve efficiency and accelerate timelines, new approaches are emerging as a powerful way to solve long-standing challenges. But where do they make a real impact, and what does effective implementation truly look like in practice?

Dr. Jiansheng Wu will share practical insights and case studies into how optimized workflows are being applied across the industry, helping teams move faster and make better-informed decisions. He will address how to overcome challenges like poor expression yields, low-affinity candidates from phage libraries, and the limited throughput of traditional methods. With vast experience in protein sciences and over 50 drug development projects, he brings both deep technical expertise and a strategic understanding of real-world challenges.

Key learning points:

  • Learn how a CHO-based expression workflow can deliver high-throughput, low-endotoxin sTCRs at scalable yields (~100 mg/L).
  • Explore how optimized phage display can be used to boost TCR binding by up to 10,000-fold, unlocking higher-quality candidates.
  • Discover practical strategies for improving candidate quality and accelerating your early-stage discovery pipeline.
  • Ask your questions live and benefit from expert insight during the Q&A session.

This session will offer a clear view of how cutting-edge methods can be used to improve your workflow, and what they could mean for the future of your work.

Register your interest now. Attendance is free >>>

SPEAKER

Jiansheng Wu, Ph.D

Jiansheng Wu, Ph.D. – Senior VP, Head of CRO Services

Dr. Wu is the Head of CRO Services and Senior VP at WuXi Biologics. With vast experience and expertise in protein sciences, he has been instrumental in establishing global protein production facilities and developing cutting-edge technologies. Having participated in over 50 drug development projects, Dr. Wu is a leading authority in automated expression, purification, and characterization of diverse proteins. Previously at Genentech for 15 years, he made significant contributions to innovative protein expression and purification technologies. 

Key learning points

  • Learn about CHO-based expression methods for producing soluble TCRs at high titers (~100 mg/L), including formats relevant to TCR-TCEs
  • Understand how phage display-based affinity maturation can be used to improve TCR binding affinity by up to ~10,000-fold (from 10–100 μM)
  • Explore how expression and affinity maturation workflows can be integrated to support generation of TCR candidates for TCR-TCE development.

FAQs

Is the webinar free?
Yes – there is no charge to watch the webinar, either live or on-demand.

When will the webinar take place?
The webinar will take place live on 22 October 16:00 PM BST. 

I’m busy. Can I watch it later?
The webinar will become available to watch on-demand shortly after the live webinar takes place.

What are the benefits of attending live?
During the live webinar, you’ll be able to ask the speakers your questions, which will then be answered during the live Q&A session towards the end of the webinar.

How long will the webinar be?
This webinar will last for up to one hour.

What do I need to watch this webinar?
All you need is a computer with an internet connection. Be sure to use headphones if in an office environment.

Do I receive a certificate?
Yes, you will receive a certificate if you attend the webinar live. The certificate will be sent with your on-demand video link.