Application note

Application note: Afucosylated mAb expression & antibody efficacy

Sino Biological’s “FucoFree” eukaryotic expression system provides high-yield and high-throughput afucosylated monoclonal antibody (mAb) production.

Currently, at least 35 glycoengineered antibodies, with their Fc fucose partially or entirely removed, have been investigated in animal models or clinical trials.

The absence of fucose on the Fc N-glycan increases IgG1 Fc binding affinity to the FcγRIIIa on immune effector cells like natural killer cells. It results in increased ADCC.

Download this application note to learn more about:

  • How antibodies work to eliminate the antigens
  • How to lower the fucosylation on Fc
  • “FucoFree” system for afucosylated mAb expression.