Application note

Application note: Developing next-gen in vitro Huntington’s disease assays

The use of high-density MEAs to probe single cell and network activity electrophysiology of a hiPSC-derived Huntington’s disease model

In this app note you will learn about:

  • The urgent need for more accurate in vitro HD models and advanced methods to analyse their functional properties
  • How high-density MEAs determine spontaneous activity, synchronous network bursting activity and axonal processes of an isogenic, precision reprogrammed hiPSC-derived HD model
  • How this disease model recapitulated the HD phenotype in vitro, including delayed neuronal network formation, decreased axonal branching and decreased spontaneous activity.