The use of high-density MEAs to probe single cell and network activity electrophysiology of a hiPSC-derived Huntington’s disease model
In this app note you will learn about:
The urgent need for more accurate in vitro HD models and advanced methods to analyse their functional properties
How high-density MEAs determine spontaneous activity, synchronous network bursting activity and axonal processes of an isogenic, precision reprogrammed hiPSC-derived HD model
How this disease model recapitulated the HD phenotype in vitro, including delayed neuronal network formation, decreased axonal branching and decreased spontaneous activity.
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