Dr Jack Scannell (CEO of Etheros Pharmaceuticals Corp)

The predictive validity crisis: Pharma’s productivity paradox – Part I

Drug discovery now costs 100 times more per FDA-approved drug…

14 October 2025 | By Dr Jack Scannell (CEO of Etheros Pharmaceuticals Corp), Dr Raminderpal Singh (Hitchhikers AI and 20/15 Visioneers)

Drug discovery now costs 100 times more per FDA-approved drug than in 1950, despite vast advances in biology and computing. The core problem is the collapse of predictive validity in preclinical models, which sits at the heart of pharma’s productivity paradox.