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Isabella Gashaw

 

PINNED CRISPR
PINNED CRISPR
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CRISPR screens and novel drug targets

According to a new study, a metabolic enzyme studied in…

6 January 2022 | By ,

According to a new study, a metabolic enzyme studied in cancer biology is key for T-cell function, offering a novel target for anti-inflammatory therapeutics. Dr Jeffrey Rathmell and Ayaka Sugiura from Vanderbilt University in the US discuss their study with Drug Target Review and why inhibiting or genetically deleting the…

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Molecular Target Validation in preclinical drug discovery

Preclinical drug target validation has the aim to increase confidence…

2 May 2014 | By , , ,

Preclinical drug target validation has the aim to increase confidence in a particular drug target. The process proves the initial hypothesis that a particular molecular target is key or even causative for pathogenic or symptomatic mechanisms in a disease. Several success factors seem to be of particular importance for the…