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Nina Graffmann

 

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Strategies for identifying predictive biomarkers of non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD), a consequence of sedentary life…

17 March 2016 | By , , ,

Non-alcoholic fatty liver disease (NAFLD), a consequence of sedentary life styles and high fat diets, has an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within genes such as PNPLA3, TM6SF2, APOC3, NCAN and PPP1R3B correlate…

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The promise of induced pluripotent stem cells for liver disease, toxicology and drug discovery

We discuss the steps required for differentiating human pluripotent stem…

9 April 2015 | By , , ,

We discuss the steps required for differentiating human pluripotent stem cells into hepatocyte-like cells, and how long this process takes and the quality control measures needed...