Whitepaper: Mitochondrial toxicity assessment

This whitepaper establishes a customised XF assay solution for the detection of mitochondrial toxicity using standardised parameters.

Direct measurement of mitochondrial oxygen consumption is a specific and sensitive indicator to assess drug-induced mitochondrial toxicity, a common issue in therapeutic development. This whitepaper introduces the Agilent Seahorse XF Mito Tox assay, a customised assay, which is used to assess mitochondrial toxicity and has the ability to identify and specifically distinguish among different modes of mitochondrial toxicity with high sensitivity.