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Cancer research

 

ADC graphic
ADC graphic
article

Shifting the ADC focus from antibody to payload

6 June 2025 | By

While ADCs continue to attract attention in oncology, many developers remain focused on antibodies – overlooking the critical role of payload design. At Sygnature Discovery, Dr Joshua Greally is leading a shift in perspective, advocating for a payload-first approach through the company’s new platform, NewPath ADC. In this interview, he…

Blood clots (fibrin clots) are usually formed to stop the bleeding during injury, Blood clots can be dangerouse when they obstruct blood flow and cause thrombosis, 3d illustration
Blood clots (fibrin clots) are usually formed to stop the bleeding during injury, Blood clots can be dangerouse when they obstruct blood flow and cause thrombosis, 3d illustration
news

Chemical hack turns platelets into drug couriers

2 June 2025 | By

Researchers at the University of Illinois have achieved the first successful metabolic labelling of platelets, a key step toward using them in targeted drug delivery. The technique could enable short-lived, precision therapies for cancer, immune conditions, and clotting disorders.

article

Strategic planning in ADC development: insights from Lonza

2 June 2025 | By

Preclinical and clinical development are critical to the success of ADCs, where early strategic decisions regarding manufacturability and scalability can make or break a project. Iwan Bertholjotti of Lonza emphasises the importance of proactive planning to avoid costly delays and ensure smooth progress towards clinical success.

Abstract vertical illustration of targeting cancer cell made of glowing neon particles. Blue geometric background depicting cancer cell screening and disease treatment medical concept. Digital art
Abstract vertical illustration of targeting cancer cell made of glowing neon particles. Blue geometric background depicting cancer cell screening and disease treatment medical concept. Digital art
article

New fixed-duration therapy could reshape CLL care

28 May 2025 | By

Advancements in chronic lymphocytic leukaemia (CLL) treatment, like the AMPLIFY Phase III trial combining acalabrutinib and venetoclax, offer less toxic and more effective options. Learn from AstraZeneca’s Benjamin Moutier about how this breakthrough highlights the potential of targeted therapies to improve outcomes and reduce treatment burden, marking a key moment…