news

First clinical trial for vaccine targeting Alzheimer’s in people with Down’s syndrome

Posted: 7 January 2016 | Nicholas Jackson | 60 comments

Plans for the world’s first clinical trial for a vaccine targeting Alzheimer’s disease-like characteristics in those with Down’s syndrome have been announced…

Alzheimer’s in people with Down syndrome

Plans for the world’s first clinical trial for a vaccine targeting Alzheimer’s disease-like characteristics in those with Down’s syndrome have been announced. 

The study will test AC Immune’s vaccine ACI-24 and is being conducted in collaboration with the University of California, San Diego (UC San Diego) Down’s Syndrome Research and Treatment Center. Funding is provided by a significant grant from the US National Institutes of Health (NIH) and an additional grant from the LuMind Research Down’s Syndrome Foundation. This is the first public/private collaboration for a clinical trial in the field of Down’s syndrome.

Individuals with Down’s syndrome (DS) have an extra copy of chromosome 21 which carries the gene for APP encoding the precursor protein of Abeta, one of the hallmarks of Alzheimer’s disease (AD). An important consequence is that individuals with DS develop AD-like characteristics at a rate three to five times greater than that of the general population and at a much younger age. Further, AD-like characteristics develop in more than 98% of people with DS over age 40 with up to 80% developing associated dementia over the age of 60. It is estimated that there are 6 million people with DS worldwide, with 400,000 in the United States.

Trial participants will be adults with DS. The objectives of the trial include studying safety and tolerability of ACI-24, its effect on induction of antibodies against Abeta, clinical and cognitive measures in adults with DS and its effect on biomarkers of AD-like pathology in DS. Participants in the study will be treated for 12 months, with 12 months follow up.

Prof. Andrea Pfeifer, CEO of AC Immune said: “We are very pleased to bring this potentially disease modifying treatment for Alzheimer’s disease into the vulnerable, genetically predisposed Down’s syndrome population. The combined knowledge and resources of AC Immune, UC San Diego, NIH and the LuMind Research Down’s Syndrome Foundation should generate much needed insight for treating the Alzheimer’s-like characteristics of those with Down’s syndrome. Additionally, this ground-breaking clinical trial could enhance our understanding of early intervention and prevention of Alzheimer’s in general.”

Dr. William Mobley, Executive Director of the UC San Diego Down’s Syndrome Research and Treatment Center, commented: “We are delighted to join our colleagues at AC Immune and the LuMind Research Down’s Syndrome Foundation in this exciting study, the first step in a process whose ultimate goal is preventing Alzheimer’s disease in people with Down’s syndrome.  That both public and private funding sources support the study signifies the importance attached to Alzheimer’s disease and the valuable insights that will come from studies of this disorder in Down’s syndrome.  We wish to thank our colleagues as we eagerly look forward to helping people with Down’s syndrome and their families and loved-ones.”

Dr. Michael Harpold,  LuMind Research Down’s Syndrome Foundation’s Chief Scientific Officer, stated: “We are very excited the LuMind Research Down’s Syndrome Foundation has been able to work and join together with AC Immune, UC San Diego and NIH in establishing the first ever private-public partnership for a clinical trial in the field of Down’s syndrome. Accelerating research and the development of new potential therapies to address the developmental intellectual disabilities and earlier onset of Alzheimer’s disease in people with Down’s syndrome represents a major part of our foundation’s mission and commitment to prevent the earlier decline and loss of important gains they have attained throughout their lives.”

Related conditions
,

60 responses to “First clinical trial for vaccine targeting Alzheimer’s in people with Down’s syndrome”

  1. Carol Croll says:

    28 year old DS daughter but live in NJ. High current cognitive level. No major hw alth concerns. Interested in studies in our area

    • Kaynat Choudhury says:

      Hi Carol,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  2. Kristina Moyce says:

    Hello,
    I am other of a son with DS and ad parents we have a vested interest in this research and it’s progress for over a year and have eagerly anticipated this phase! I would greatly appreciate it if someone could contact me to discuss the possibilities of including our son in this trial or having him as a qualified candidate for future research. I am not sure if we would qualify as we are in Canada but if it’s any consolation it’s been pre discussed with his geneticist and I have the support of our medical team. I eagerly anticipate your response!
    Respectfully
    Kristina Moyce

    • Kaynat Choudhury says:

      Hi Kristina,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  3. Linda Robinson says:

    So glad this happening. My 35 yr old daughter was diagnosed with early onset of dementia and Aricept did not work. Any chance patients at UC DAVIS Sacramento can participate?

    • ann o'dell says:

      Linda,
      I have a son with DS who is 31 and I am wondering what signs your daughter exhibited before being diagnosed. Any info would be appreciated. Thank you!
      Ann

    • Kaynat Choudhury says:

      Hi Linda,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  4. Nancy Tallmadge says:

    It is believed that my 56 yr. old DS son is in the early stages of Alz……….on Aricept from his GP, seeing a neurologist and urologist………all of this is likely too late for him…………BUT, I would appreciate any information and suggestions………..

    • Kaynat Choudhury says:

      Hi Nancy,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  5. Gail Koombes says:

    Are there studies in BC Canada. My brother in law isnow 51 and showing signs.

    • Kaynat Choudhury says:

      Hi Gail,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  6. I have a 34 yo daughter with DS and wondered about the possibility of having her go on to the trial. Any advice and suggestions appreciated

    • Kaynat Choudhury says:

      Hi Eva,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  7. Katheryn Wells says:

    I AM BOTH GUARDIAN AND MOTHER OF A 38 YEAR OLD SON WHO IS DOWN SYNDROME. I WOULD BE INTERESTED IN IFORMATION CONCERNING YOUR TRIAL. HIS RESIDENCE IS IN TEXAS.
    THANK YOU.

    KATHERYN WELLS
    PO BOX 50636
    MIDLAND TX. 79710.

    • Kaynat Choudhury says:

      Hi Katheryn,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  8. gayle bellemare says:

    So happy to see this progress for those with DS and for those impacted by AD in general. I am wondering if you will be including DS patients who have been diagnosed with AD or if this will be limited to those who are not displaying symptoms and will there be any Canadian involvement? Thank you!

    • Kaynat Choudhury says:

      Hi Gayle,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  9. lynda schaffel says:

    My daughter Lisa is 31 with Down Syndrome. She is high functioning, and has no major health concerns. I would love for her to be in the study. We live in Oklahoma City.

    • Kaynat Choudhury says:

      Hi Lynda,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  10. Nancy Pope says:

    We have a 33 year old son with DS. He is high functioning. We would be interested in being considered for his inclusion in your study or any being done here on the east coast.

  11. Marie Kalb says:

    my daughter, is 40 yrs. Old with Down Syndrome, has been diagnosed with Early onset Alzheimer’s. She was on aricept & namenda For 3 years
    and has been on Namenda and exelon now with 2 yrs. Would she be a possibility for this clinical trial. I eagerly await your response.

    • Kaynat Choudhury says:

      Hi Marie,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  12. Randy says:

    This is a promising development. As a parent of a 14 year old daughter with DS I am most appreciative of the work of researchers and LuMind. She participated in the Clematis drug study and it was a great experience.

  13. Jane says:

    Our son, age 36, has early onset dementia. He is on Namenda and Excelon. I am interested in discussing this with other parents going through the same thing.

  14. Samantha tate says:

    My daughter is 8 months old, with DS. Have read up a bit on the dementia that could occur in my child. Feel this is a good study to be carried out. Love and support.x

    • Kaynat Choudhury says:

      Hi Samantha,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  15. Bunny Gierczak says:

    i have a 24 y.o. Son With Down syndrome. Would love some additional information regarding this study and the protocols

    • Kaynat Choudhury says:

      Hi Bunny,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  16. Kelly says:

    I have a 33 year old daughter with Down Syndrome. She is very bright and to date shows none of these signs, however, it breaks my heart to think that, all too soon, this can happen. We too would love the opportunity for her to be a part of this study. Hoping to hear from you. Thanking you for all you are doing to help my daughter and the many wonderful individuals with Down Syndrome!!

    • Kaynat Choudhury says:

      Hi Kelly,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  17. Kris Henson says:

    I am so glad to hear anout these trials showing that our children are worthy of a fight. My son is 14 years, and is extremely high functioning without missing out on the teenage attitude of course. I would be very interested in being a part of this group, whilst perhaps too young and in Australia, at least to be informed with your progress on this trial. Thank you in advance
    Kris Henson
    Perth
    Australia

    • Kaynat Choudhury says:

      Hi Kris,

      Great to hear from you in Australia!

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      Subscribing to our magazine might also help as we often have news stories related to Down Syndrome, Alzheimer’s and dementia.

      We really hope this information helps!

      Drug Target Review

  18. Sharon Mercer says:

    I am an adopted mom, legal guardian, of a 45 year old women, who is currently show early symptoms of memory loss. I an very interested in seeing if she would qualify for your trials. I am very interested in any therapy. She was tried on Airicept with poor response.

    Thank you

    • Kaynat Choudhury says:

      Hi Sharon,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  19. D Schultz says:

    i have a DS son that is a healthy 25 year old. We live in Louisiana. Would love more information on this study.

    • Kaynat Choudhury says:

      Hello,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  20. Kristen says:

    I have a 44 year old ds son. He works 40 hours a week as a janitor. He is currently taking citalopram. Would love for him to be involved somehow in this trial. We are in Seattle.

    • Kaynat Choudhury says:

      Hi Kristen,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  21. Joyce Page says:

    I have a 26 year old healthy daughter with DS. We are in Idaho. What are the requirements to be in the study?

    • Kaynat Choudhury says:

      Hi Joyce,

      Unfortunately, we do not have access to the list of participants nor information about requirements. You can find out more by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

    • Kaynat Choudhury says:

      Hi Joyce,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  22. Susie Coles says:

    I take care of my forty-seven year old brother who is a fairly high functioning and has Downs. I would be extremely interested in participating in a trial. We live in El Paso, Texas. May be moving to Nashville at some point soon. Over the past two years I have noticed some changes but overall he is doing quite well. So very proud of him!

    • Kaynat Choudhury says:

      Hi Susie,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  23. Tina Root says:

    I have a 56 year old brother with DS. He is showing definite signs of AD. Any chance for help or advice would be appreciated.

    • Kaynat Choudhury says:

      Hi Tina,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  24. Clausine Honda says:

    21 Y/O daughter … Healthy and high functioning. Interested in trial. Live in the Los Angeles area.

    • Kaynat Choudhury says:

      Hi Clausine,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  25. sharleen says:

    Please send info that may be helpful for our 34 year old daughter regarding your studies and the trial.

    • Kaynat Choudhury says:

      Hi Sharleen,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  26. Liana King says:

    My brother is 62 years old and has exhibited signs of Alzheimer’s since around 2010. Andy is 62 and in very good overall health! He has days when we have the same conversation a few times, and days when he is right on. There are friends he may not recognize and strangers he is ready to hug. I think Andy would be an awesome candidate as a man in “advanced” years.

    Liana
    Sister, Caregiver, Companion, Guardian

    • Kaynat Choudhury says:

      Hi Liana,

      Andy sounds great!

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  27. Beth Oster says:

    My daughter is 24 years old and has DS. I am interested in having her participate or screened to participate in this study. In addition to her having DS, AD runs in our family. We live in PA. Any information would be greatly appreciated.

    • Kaynat Choudhury says:

      Hi Beth,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  28. My son with Down Syndrome he is 25 was diagnosed with Dementia a year ago. He started to stop going out into the community and doing the things he liked doing such as swimming and socializing with friends. He also has a hard time taking a shower, shaving etc.. He goes to his Post High program has hard time getting up and getting on the bus. He never use to hit us before however we are now getting hit. He seems confused often .. I have never meet another person with DS this young that has Dementia.

  29. Janine Dickerson says:

    I am the mother of a 23 year old daughter with Down’s. She is high functioning and doesn’t have many issue but sleep apnea. I would love to have her participate in this trial study. It breaks my heart to know that one day this could possibly happen to her and others like her. We are in Atlanta Ga and would to hear from you. Blessings

    • Kaynat Choudhury says:

      Hi Janine,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  30. Sandy Coleman says:

    I have a son with Ds who is 30 and fairly high functioning. He works part time and just started a post secondary program. We are very interested in participating in this program. We are close to a new Down Syndrome clinic in West Palm Beach. It would be great if we could participate.

    • Kaynat Choudhury says:

      Hi Sandy,

      Unfortunately, we do not have access to the list of participants. You can find out more about participating by emailing AC Immune directly though. Their email address is [email protected]. Checking the Lumind Foundation website is also very good to find out about trials you can participate in. Click here to visit the site.

      We really hope this information helps!

      Drug Target Review

  31. Christine Barlow says:

    I have 30 year old twin daughters with DS .One of them has had signs of Dementia for a year now. I cry every day because there is nothing I can do to help her. I recognize the signs and symptons because my mother suffered with it.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Send this to a friend