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Hoag Memorial Presbyterian Hospital

 

3D illustration of damaged neurons with disrupted myelin sheaths, representing neurodegeneration in conditions such as Alzheimer’s disease.
3D illustration of damaged neurons with disrupted myelin sheaths, representing neurodegeneration in conditions such as Alzheimer’s disease.
article

Inside the Alzheimer’s study backing stem cells, not drugs

26 August 2025 | By

In this first-in-human Alzheimer’s study, Wnt-activated autologous stem cells are delivered intracerebroventricularly (directly into the brain) to address neuronal loss, while also reducing amyloid and tau biomarkers and improving cognition. Early data from this regenerative approach could help early drug discovery teams shape target selection, biomarker development and trial design.