Monash Institute of Pharmaceutical Sciences (MIPS)

New frontiers in G protein-coupled receptor drug discovery

10 December 2018 | By Christopher J. Langmead

G protein-coupled receptors (GPCRs) are seven transmembrane spanning proteins that mediate the physiological responses to a broad array of stimuli, including photons, biogenic amines, peptides and large proteins. They represent the target of approximately one-third of all approved drugs,1 yet paradoxically remain a relatively under-exploited protein class.