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New organoid model helps test spinal cord regeneration drugs
Northwestern scientists have grown human spinal cord organoids to test therapies that could reduce scarring and promote nerve regrowth in patients.
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Memory-linked brain cells offer new obesity target for future therapies
Scientists have identified a brain circuit that connects contextual memory with appetite, advancing understanding of binge eating and obesity while highlighting a promising new target for drug discovery.
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Siglec-15 identified as key target in paediatric brain cancer
Scientists have identified a previously unknown lysosomal signalling pathway that drives growth in drug-resistant SHH medulloblastoma, which could lead to more precise and less harmful treatments for children with aggressive brain tumours.
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Why ageing must become central to Parkinson’s research
An international team of scientists is urging researchers to put ageing at the centre of Parkinson’s studies, arguing that it has been overlooked for too long.
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AI begins to enter Alzheimer’s drug discovery pipelines
Artificial intelligence is increasingly used to analyse large, multimodal Alzheimer’s datasets and inform target discovery and trial design. A new JPAD special issue highlights how these methods are moving from experimentation towards practical application in drug discovery.
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Alcohol addiction linked to major brain gene changes
New research shows chronic alcohol use rewires gene activity in human brain regions that control reward and decision-making, which could inform the development of more effective addiction treatments.
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Organ-on-a-chip tests immune wafer for glioblastoma
Researchers at the University of Cincinnati are developing an immune-stimulating wafer to be used after brain tumour surgery, aiming to overcome long-standing barriers in the treatment of glioblastoma and inform new personalised therapies.
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How Epstein-Barr virus could trigger multiple sclerosis
New research has demonstrated how a common virus may trigger the immune attack that leads to multiple sclerosis, providing a deeper look into a disease that affects nearly one million people in the US.
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Targeting mGlu7 could lead to new anxiety and PTSD treatments
Addex Therapeutics has published new research showing that targeting the mGlu7 receptor with a negative allosteric modulator can disrupt fear memory reconsolidation, offering a potential new approach to treating anxiety and PTSD.
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New psilocybin data highlights challenges for anorexia drug development
New preclinical research shows that psilocybin’s behavioural and inflammatory effects vary with metabolic state and exercise, highlighting key biological variables that could inform drug discovery, target selection and patient stratification in psychedelic therapeutics.
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Tau protein changes reveal new targets for neurodegenerative diseases
New research has revealed that tau-driven neurodegenerative diseases each have distinct chemical signatures, challenging current one-size-fits-all approaches to diagnosis and treatments.
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New 3D brain organoids reveal how glioblastoma evades treatment
Researchers have developed 3D human brain organoids that reveal how glioblastoma interacts with brain and immune cells, discovering hidden drivers of tumour invasion.
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New blood test could detect Parkinson’s years before symptoms
Scientists have identified early blood biomarkers for Parkinson’s disease, revealing a narrow window in which the condition could be detected years before symptoms appear.
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CC023 mice reveal how ALS can develop after viral infections
Researchers have discovered a mouse strain that mirrors ALS in humans following a viral infection, offering new insights into how the disease develops, potentially opening new pathways for early diagnosis and drug development.
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Brain discovery could improve drugs targeting amyloid diseases
New research shows the brain can intentionally form amyloids to store memories, challenging decades of thinking about neurodegenerative disease and pointing towards new strategies for drug discovery.
