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ASD-like symptoms in chicks caused by neonicotinoid
Japanese researchers found an ASD-like behavioural impairment in chicks, suggesting a molecular pathway of ASD pathogenesis.
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Novel protein identified that contributes to tau neurotoxicity in Alzheimer’s disease
US researchers have identified a protein that interacts and enhances the spread of neurotoxic species of tau, which is primarily found in neurons that appear abnormal in the brains of Alzheimer’s disease patients.
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Highlights from PEGS Europe’s Protein & Antibody Engineering Summit
Drug Target Review’s Ria Kakkad recently travelled to Barcelona to attend PEGS Europe’s Protein and Antibody Engineering Summit. In this article, she shares her highlights from the event.
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Green tea and resveratrol could be the next step for Alzheimer’s disease research
US researchers, using a 3D neural tissue model, found that compounds from green tea and resveratrol could diminish Alzheimer’s amyloid plaques in lab tests, with no side effects.
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Scientists identify neurotransmitter that could help treat Parkinson’s
The study, involving mice, found that the neurotransmitter can act as a break to dopamine.
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Potential treatment for neurological disorders targets brain cells
UCL researchers have developed a possible new treatment for neurological and psychiatric diseases, that works by reducing the excitability of overactive brain cells.
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How ageing triggers Huntington’s disease
A new study found that as patients age, Huntington’s disease gradually impairs the important cellular housekeeping process autophagy, which is responsible for eliminating waste from cells.
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Study offers new insights into genetic mutations in ASD
The study’s findings have important implications for better understanding the neurological basis for ASD and developing effective therapies for patients.
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Scientists discover anti-inflammatory molecules SGDGs decline in the ageing brain
The molecules, called SGDGs, may lead to new ways to treat age-related neurological diseases.
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New study expands range of potential Alzheimer’s drugs
Researchers have connected the loss of alpha-B insulin receptors in brain microvessels as contributors to insulin resistance and cognitive decline, with Alzheimer’s disease.
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How neurons stimulate the brain’s microglia
A new MIT study highlights ailing neurons may activate an inflammatory response from the brain’s microglia immune cells.
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Scientists discover multiple pathways of the 5HT2a receptor activated by psychedelics
The new LSD-like compounds activated the 5HT2a receptor, a receptor stimulated by serotonin, without causing hallucinations.
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Making lab-grown brain organoids ‘brainier’
UCLA-led team discovers that using early-stage stem cells is a key to producing structures that are reliable models of disease.
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Targeting tau – chasing a treatment for Alzheimer’s
Alzheimer’s disease remains one of the largest challenges for the global ageing population. In this article, Victoria Rees, Editor of Drug Target Review, reviews some of the latest research, highlighting how progress has been made in understanding tau as well as how to potentially target this protein as a therapeutic strategy against…
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3D imaging helps to better understand the early stages of Alzheimer’s disease
Researchers have successfully characterised a part of the brain that shows the earliest accumulation of tau protein, an important biomarker for the development of Alzheimer's disease.
