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Therapeutics

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Advancing the understanding of placenta accreta spectrum disorder

1 February 2024 | By Drug Target Review

A new study has identified targets to refine diagnostic tests, track disease progression, and discover more effective therapies.

news

New insights into the functions of inflammasomes

3 January 2024 | By Drug Target Review

For diseases mediated by NLRP3, AIM2, NLRC4, and Pyrin, understanding inflammasome biology could identify therapeutic targets.

webinar

Advancing therapeutics targeting cytokines with functional cell-based assays

3 January 2024 | By Eurofins DiscoverX

Watch this webinar to discover functional cell-based assays for characterizing novel therapeutics & biosimilars targeting cytokines in inflammation & oncology.

whitepaper

Beyond the lab: RNA

6 December 2023 | By Drug Target Review

Download this exclusive content focusing on new RNA editing technology, the challenges and opportunities presented and the potential of RNA-based therapeutics.

news

New method to develop therapeutics for autoimmune diseases

30 November 2023 | By Drug Target Review

A technique that can sort millions of CRISPR-edited cells based on their secretion patterns has been developed to treat autoimmune diseases.

news

New algorithm identifies a novel CRISPR-Cas system

24 November 2023 | By Drug Target Review

Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.

news

Breast cancer cells invade by a physical mechanism

15 November 2023 | By Drug Target Review

Findings from using a 3D hydrogel to study how cancer cells physically tear the basement membrane offers promise for targeted treatment.

news

Improving ovarian cancer outcomes with artificial intelligence

13 November 2023 | By Drug Target Review

Researchers have developed an AI based model that is 80 percent accurate in predicting the therapy outcome of high-grade ovarian cancer.

Assays for protein degradation therapeutics to accelerate undruggable proteome discoveries

article

Understanding intracellular processes improves LYTACs therapy

7 November 2023 | By Ellen Capon (Drug Target Review)

New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.

news

Microcapsule-loading exosomes to treat vitreoretinal diseases

24 October 2023 | By Drug Target Review

Scientists have developed ExoCaps, self-healing microcapsules that are more feasible than other cell-based technologies.

news

Newly discovered mechanism behind cognitive decline in aging

27 July 2023 | By Izzy Wood (Drug Target Review)

US researchers say new mechanism could lead to new drugs and therapies to treat normal cognitive decline in aging.

Exosomes,Extracellular,Vesicles,Vaccine,Coronavirus,Covid,19,Exocytosis,Molecular,Structure

news

Extracellular vesicles could slow spread of fibrosis

26 July 2023 | By Izzy Wood (Drug Target Review)

US researchers studied the extracellular vesicles of fibrosis and find potential avenue for new treatments and therapeutics.

webinar

Functional assays for the development of agonistic antibodies

20 July 2023 | By Eurofins DiscoverX

Watch this webinar to discover qualified bioassays assessing therapeutic antibody mechanisms, case studies about agonistic effects in antibodies initially deemed antagonistic, and explore Fc receptor impacts on antibody response in co-culture assays.

article

Rare autoantibody diseases: an innovative targeted pathway

7 July 2023 | By Dr Katie Abouzahr

Dr Katie Abouzahr outlines how precision targeting utilising the neonatal fragment crystallisable receptor pathway may provide accessible new treatments for autoantibody diseases.

article

Antibody Drug Conjugates: windows of opportunity

4 July 2023 | By Dr Jeff Mocny (Abenza), Dr Petra Dieterich (Abenza), Ian Glassford (Abenza)

This articles aims to drive understanding in Antibody Drug Conjugate (ADC) drug development to improve patient outcomes. Petra Dieterich, Ian Glassford, and Jeff Mocny, Scientific Leaders at Abzena discuss real-world data that is challenging traditional scientific thinking on the ADC therapeutic window. The authors also explore the need for further…

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Therapeutics