Guide: Screening biologic candidates with nanoDSF

Read this guide about nanoDSF for high-resolution measurements of thermal stability parameters, common CQAs for biologics developability assessment.

Nano-differential scanning fluorimetry (nanoDSF) is a tool of choice to measure thermal stability, which is one of the most common critical quality attribute (CQA) for biologic candidates.

Read this mini-guide to learn:

  • How nanoDSF uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton
  • Why high-resolution unfolding data is critical to obtain stability information about mAbs
  • What some real-life examples of nanoDSF data look like.