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Percy Selasi Agogo-Mawuli



Rapidly transitioning from in silico hits to leads on ‘undruggable’ pain targets

13 December 2022 | By ,

Opioid addiction is an ongoing crisis in the US. Researchers have identified a key regulator that shapes analgesic and aversive outputs of kappa opioid receptor signalling, finding lead inhibitors of this previously ‘undruggable’ target class – the Regulators of G protein Signalling (RGS proteins) – to help re-establish non-addictive kappa…