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Molecular biology

New protein structures modeling: the Nobel Prize in chemistry. Geometrically shaped proteins can change their shape due to external influences. Pharmaceuticals, nanomaterials, tiny sensors, AI, 3D

news

Boltz-1: A new open-source AI tool for drug discovery

31 December 2024 | By Drug Target Review

MIT's new open-source AI model, Boltz-1, could transform drug discovery by accurately predicting protein structures, offering global access to researchers.

Preparing cryo-electron microscopy grid sample in liquid nitrogen with protective gloves

news

New insights into adhesion GPCRs spark drug design potential

27 December 2024 | By Drug Target Review

Researchers at the University of Chicago have revealed the complete structure of adhesion GPCRs, uncovering new activation mechanisms that could lead to more targeted drug treatments.

Sickle cell anemia, 3D illustration. Clumps of sickle cell block the blood vessel

news

New data shows benefits of automated blood exchange for sickle cell disease

24 December 2024 | By Drug Target Review

New studies highlight the potential of automated blood exchange to improve outcomes for sickle cell disease patients.

Cancer blood test and malignant disease screening for early detection of cancers

news

Radiotracer targets key cancer biomarker for precision treatment

23 December 2024 | By Drug Target Review

A breakthrough in molecular imaging could transform how doctors target solid tumours, offering more personalised and effective treatment options.

Sickle cell disease medical concept 3D Illustration

news

Tessera’s gene editing offers hope for sickle cell patients

18 December 2024 | By Drug Target Review

Find out how Tessera's latest advancements in gene editing bring promising solutions to treat sickle cell disease.

article

In vivo CAR T: Faster, cheaper, and more effective cancer care

16 December 2024 | By David Fontana (Chief Operating Officer at Umoja Biopharma)

Find out how in vivo cell therapies could transform cancer treatment by providing faster, more affordable, and accessible options for more patients.

Antibodies, immunoglobulin Ig proteins 3D medical image.

news

Refeyn launches software platform to automate mass photometry workflows

13 December 2024 | By Drug Target Review

Refeyn's new software automates mass photometry workflows, delivering faster and more consistent results for bioanalytical applications.

Concept of Huntington's Disease write on sticky notes isolated on Wooden Table.

news

Novartis licenses innovative treatment for Huntington’s disease

12 December 2024 | By Drug Target Review

Novartis has teamed up with PTC Therapeutics to develop PTC518, a groundbreaking treatment that targets the cause of Huntington's disease, offering new hope for patients.

Concept of a human head with a puzzle in the middle.

news

Key enzyme discovery marks a step forward in Alzheimer’s treatment

10 December 2024 | By Drug Target Review

Scientists have decoded the 3D structure of a key enzyme linked to Alzheimer's disease. This breakthrough opens up new possibilities for targeted drug development and better treatment options.

news

FDA greenlights AI-developed drug targeting solid tumors

4 December 2024 | By Drug Target Review

Insilico Medicine’s AI-designed drug ISM5939 has received FDA IND clearance for treating solid tumours. By targeting ENPP1, it enhances anti-tumour immunity and is set to begin Phase I trials soon.

news

New DNA nanostructures set to transform cancer treatment

3 December 2024 | By Drug Target Review

A University of Sydney study reveals how DNA origami can build programmable nanostructures, with promising applications in targeted drug delivery and nanorobotics.

news

CNIC identifies key mechanism in fat cells to combat obesity

2 December 2024 | By Drug Target Review

CNIC researchers have identified a mechanism in fat cells that helps them safely store excess fat, offering new insights for combating obesity and related metabolic diseases.

Blood-brain barrier (BBB) in the human brain - closeup view 3d illustration

news

Blood-brain barrier breakthrough for ALS and Alzheimer’s disease

27 November 2024 | By Drug Target Review

A new blood-brain barrier-crossing platform enables the delivery of therapeutic molecules to the brain, offering potential treatments for ALS and Alzheimer’s disease.

news

KRAS variants in human pancreatic cancer: new key findings

4 October 2024 | By Drug Target Review

Researchers have identified underlying KRAS mutations which drive associated risk of particular clinical outcomes.

news

Largest multi-omics study of colorectal cancer to date

15 August 2024 | By Drug Target Review

Five distinct CRC prognostic subtypes were identified, which could revolutionise the way CRC is diagnosed and treated.

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Molecular biology