Drug Target Review

Small tags, big advances: studying endogenous proteins in their native context

2026-06-22T07:00:00+01:00By Dr Joshua Sopp

By combining CRISPR knock-in with small peptide tags, researchers can study proteins in their native cellular context, generating more predictive data for translational drug discovery.

Article
Cerebral organoids reveal how Ebola virus persists in neural tissue
2026-06-18T16:01:00+01:00By Drug Target Review
How does Ebola virus survive long after recovery? A new study using human cerebral organoids explores viral persistence in neural tissue and the growing role of organoid models in drug discovery research.
Article
Pomegranate-derived compound shows therapeutic potential in heart disease
2026-06-15T07:00:00+01:00Contributor Professor Dipak Ramji, By Drug Target Review
Researchers at Cardiff University have identified urolithin A – a compound produced by gut bacteria during the metabolism of substances found in pomegranates – as a potential new approach for treating cardiovascular disease.
Article
Flow-based human tumour models reveal immune responses missed by static culture
2026-06-15T08:00:00+01:00By Dr Finola Cliffe
Static cultures may not tell the whole story when it comes to immunotherapy performance. Results from the Mera™ flow-based human tissue model show stronger T-cell activity and cytokine responses under physiological flow, highlighting the role of dynamic immune–tumour interactions in preclinical testing.

Opinion and interviews

Physics-based modelling offers a new way to study drug targets

2026-03-26T14:15:00+00:00By Drug Target Review

Australian start-up OmnigeniQ has demonstrated what it describes as the first deterministic, physics-based computation of a human protein in its native state.

Webinar

Where NAMs stand in early drug discovery: an expert discussion

From expert task to lab routine – Membrane protein purification and analysis simplified

Sponsored by Analytik Jena GmbH + Co. KG

A new way to tackle the most challenging drug targets: Discover a fully automated, detergent-free purification workflow that isolates membrane proteins in their native 3D structure in as little as three hours and with minimal hands-on time. Learn how to perform subsequent digital miniaturization and qPCR-based stability analysis with compact solutions that integrate seamlessly into your lab.