Nabriva Therapeutics announces financing to advance clinical development of new class of antibiotics

Posted: 7 April 2015 | Victoria White

Nabriva, a biotechnology company focused on developing pleuromutilins, has announced the successful completion of a $120 million Series B financing…

Nabriva Therapeutics AG, a biotechnology company focused on developing pleuromutilins, a new class of antibiotics for the treatment of serious infections caused by resistant gram-positive and gram-negative bacteria, has announced the successful completion of a $120 million Series B financing.

The financing was led by new US based investors Vivo Capital and OrbiMed, and includes EcoR1 Capital, Boxer Capital of Tavistock Life Sciences and new investment from existing investor HBM. Existing investors Phase4 Partners, Wellcome Trust, GLSV and Novartis Venture Fund also participated in the round. Representatives of Vivo Capital and OrbiMed will be joining the Nabriva Supervisory Board.

Nabriva’s lead product, lefamulin, is the first systemically available pleuromutilin for human use

The initial tranche of $50 million will enable Nabriva to progress its lead product, lefamulin, into clinical phase 3 studies in community-acquired bacterial pneumonia (CABP) and to continue the development of its product pipeline. Lefamulin (BC‑3781) is the first systemically available pleuromutilin for human use and is entering pivotal phase 3 studies for the treatment of community-acquired bacterial pneumonia (CABP). Lefamulin possesses potent in vitro activity against the most common pathogens associated with CABP, specifically S. pneumoniae, H. influenzae, M. catarrhalis, S. aureus, M. pneumoniae, L. pneumophila, and C. pneumoniae, including multi-drug resistant strains.

Preclinical programs include the Extended Spectrum Pleuromutilins (ESPs), a new generation of antibacterials possessing in vitro activity against urgent and serious bacterial threats identified by the Centers for Disease Control and Prevention (CDC) including carbapenem-resistant Enterobacteriaceae (CRE), while maintaining the antimicrobial spectrum of lefamulin.  As such, the ESPs represent much needed development of a novel class of antibacterials, with a unique mechanism of action, directed at addressing this significant unmet medical need.

Dr Colin Broom, Chief Executive Officer of Nabriva, said: “We are delighted to have attracted investment from some of the world’s leading healthcare investors. It is validation of Nabriva’s approach in developing the pleuromutilin antibiotic class, which has a unique mechanism of action thereby helping to combat the current and evolving emergence of resistance to currently available antibiotics. We appreciate the commitment of our existing investors and the continued confidence they have shown in Nabriva. We welcome Dr Chen Yu from Vivo and Mr Chau Khuong from OrbiMed to the Supervisory Board and look forward to benefiting from their expertise as we advance our programs.”

Dr Chen Yu, Managing Partner at Vivo Capital, said: “We are excited to work with Nabriva in the development of drugs to address the urgent issues around antibiotic resistance.”

Dr Denise Pollard-Knight, Chairman of the Supervisory Board of Nabriva, added: “The rapid spread of multi-drug resistance is a growing public health threat recognised by global policy makers as governments commit resources and funding to tackle this problem. The development of novel antibiotics with a unique mechanism of action against these pathogens is critically important in developing a new generation of drugs. This Series B is a strong financial and scientific endorsement and provides Nabriva with a solid foundation to build a patient-centric global biopharmaceutical company.”

For more information about Nabriva, please visit

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