Understanding the genetic origins of disease variation
Researchers, using high-resolution mapping and mathematical modelling, have found mechanisms controlling mutation-driven diseases.
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Newly discovered mechanism behind microhaemorrhages
Findings about how erythrocytes interact with brain capillaries offers new potential treatments for brain microhaemorrhages.
Novel computational model to study cancer dynamics
An advanced computational model enables scientists to study how cancer cells navigate through blood vessels.
Discovery of molecular pathway could target lung cancer
New findings about how RBM10 inhibits lung cancer growth offers potential for an anti-cancer drug and more personalised treatment.
Pancreatic cancer initiates an immune system response
Studying pancreatic ductal adenocarcinoma tumours, researchers discovered 25 antibodies that responded to antigens.
New method to develop therapeutics for autoimmune diseases
A technique that can sort millions of CRISPR-edited cells based on their secretion patterns has been developed to treat autoimmune diseases.
Potential therapeutic target for ventricular fibrillation found
A signalling mechanism for ventricular fibrillation involving the stress kinases p38γ and p38δ has been discovered.
Neuropsychiatric symptoms due to excessive brain inflammation
In Alzheimer’s disease patients, irritability and anxiety is likely caused by neuroinflammation, which indicates new therapeutic pathways.
New AI model can evaluate invasive breast cancer outcomes
Combining cancerous and non-cancerous cell patterns, the AI model evaluates breast cancer outcomes better than expert pathologists.
New contamination-detection test to improve T-cell therapy
Method to improve sterility assurance in biopharmaceutic manufacturing will lead to better patient outcomes.
Mitochondria-targeting antibiotics reduce aging in C. elegans
Treating C. elegans with inhibitors of small or large mitochondrial ribosomes extended their median lifespan.
Y chromosome discovery could advance personalised medicine
Researchers have completely decoded the human Y chromosome, which may result in more effective treatment for digestive disorders.
New algorithm identifies a novel CRISPR-Cas system
Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.
Potential of small molecule therapeutics for Barth syndrome
Novel findings about the tafazzin gene offers a potential new target and drug candidate for Barth syndrome.
Noncoding RNA could be a new target for acute myeloid leukaemia
Discovery about the DNA of leukaemia cells suggests promising target for gene therapy in paediatric oncology.
