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Integrin αV and β5 partner to drive cancer cell growth
A novel cellular mechanism has been uncovered with the use of CRISPR gene-tiling technology, which could advance oncologic therapies.
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CRISPR
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Whitepaper: Empower CRISPR cell engineering with single cell sorting
Learn how scientists like you are using Namocell single cell sorters through summaries of seven recent peer-reviewed citations.
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Augmenting cancer immunogenicity through MHC class I
A novel technology can reduce tumour sizes significantly and improve treatment efficacy when used with existing immunotherapy.
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CRISPR activation: quicker diagnosis of rare genetic diseases
Using CRISPRa to activate genes in readily accessible cells provides an effective and accurate diagnosis of genetic diseases.
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Off-switches developed for CRISPR-Cas3 technologies
AcrlC8 and AcrlC9 prevent the CRISPR-Cas3 machine from binding to its DNA target site, providing a safer way to engineer the genome.
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Mechanisms underlying pioneer TF-mediated gene repression
Researchers have made surprising and important findings that may influence organoid and cell reprogramming studies.
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RBM5: potential drug target for acute myeloid leukaemia
RBM5 removal from cells meant that HOXA9 mRNA levels were greatly reduced, which could lead to therapies targeting HOXA9-driven leukaemia.
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Article: Tips and Tricks for Leveraging Advanced Flow Cytometry
Tips and tricks for fully leveraging Advanced Flow Cytometry.
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New method to develop therapeutics for autoimmune diseases
A technique that can sort millions of CRISPR-edited cells based on their secretion patterns has been developed to treat autoimmune diseases.
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New algorithm identifies a novel CRISPR-Cas system
Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.
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Handbook: Advanced flow cytometry handbook
Don’t miss out on the easier way to do flow cytometry. Learn how to bring speed, throughput, multiplexing and miniaturization, to your bench.
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Human-derived proteins used in DREAM tool
CRISPR-DREAM tool used to activate insufficiently expressed genes and convert skin cells to induced pluripotent stem cells (iPSCs).
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New research holds significance in regulating T cell function
New research shows T cells use the nuclear receptor RARα not just for gene regulation, but also to trigger cell surface events that activate them against pathogens and cancer.
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Vaccines against parasitic disease
In Columbus, Ohio, scientists have made significant strides in developing vaccines to combat leishmaniasis, a disfiguring skin disease, through animal studies.
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Huntington’s disease and potential therapies
In this exclusive interview with Young Kwon, CEO of Alchemab, we discuss new platforms that are revolutionising how researchers identify naturally occurring antibodies in resilient individuals, opening up new possibilities for the development of disease-modifying therapies.
