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New algorithm can predict when cancer will resist chemotherapy
The ML algorithm explores how genetic mutations collectively influence a tumour’s reaction to drugs impeding DNA replication.
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Genetic Analysis
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Advancing the understanding of rare heart conditions
A potential link between truncating variants and the development of DCM has been found, and a patient-focused registry about PPCM was made.
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Changes in CD4+ T cells associated with autoimmune diseases
Genetic factors that promote disease development accumulated in CD4+ T cells exhibiting specific gene programmes.
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Unexpected patterns in DNA mutations identified
Disruptions in TP53 and RB1 are key influencers that cause changes in the risk of mutations across chromosomes.
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Neurodevelopmental defects seen in mini-brains with ANG mutation
Researchers found that ANG in its mutated form slows stem cell differentiation, resulting in neurodevelopmental defects in adult nerve cells.
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How gene regulatory networks maintain FLT3-ITD mutated AML
Using shRNA screening enabled researchers to investigate the roles of individual specific factors in maintaining the network found in AML.
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Potential target found for CDKL5 deficiency disorder
Using phosphoproteomics, the calcium channel Cav2.3 was found as a target to treat a type of genetic epilepsy, CDKL5 deficiency disorder.
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Investigating the genetic changes of the DDX3X gene
Using saturation genome editing, researchers have created a map of disease-causing mutations for neurodevelopmental disorders and cancer.
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Beyond the lab: RNA
Download this exclusive content focusing on new RNA editing technology, the challenges and opportunities presented and the potential of RNA-based therapeutics.
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New method to develop therapeutics for autoimmune diseases
A technique that can sort millions of CRISPR-edited cells based on their secretion patterns has been developed to treat autoimmune diseases.
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Y chromosome discovery could advance personalised medicine
Researchers have completely decoded the human Y chromosome, which may result in more effective treatment for digestive disorders.
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DNA epigenetic changes: a key cause of cancer
Analysis of cells shows many regions in DNA are differentially activated or inactivated in a cancer-specific manner.
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Understanding Z-RNA structure could provide new treatments
A $1.2 million grant has been given to observe how Z-RNA is formed and explore its benefits for various diseases.
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Alternate origin discovered for brain mosaicism and focal epilepsy
Researchers gain insight into how brain tissue is impacted differently by genetic problems compared to the rest of the body.
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Targeting immune cells may help treat atrial fibrillation
New MGH study finds that macrophages and macrophage-produced proteins contribute to heartbeat irregularities, thus targeting these cells can aid atrial fibrillation treatment.
