news
Enhanced NPC cultivation furthers understanding of kidney disease
Induced NPCs facilitate the creation of patient-specific organoid models and improve identification of nephron targeted drugs.
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Organoids
news
New TEC organoid model to study thymus function
The new organoids demonstrate a greater diversity of TECs in culture and are capable of maturing T cells.
podcasts
Investigating the promising future of organoids
In this episode, we discuss the current advantages and limitations of using organoids, as well as where the field is heading.
news
Mini-colons reveal complex process of tumorigenesis ex vivo
The mini-colons are topobiologically complex, can be induced to develop tumours in targeted areas and reduce the use of animal models.
news
KCNJ2 inhibition: a therapeutic target for traumatic brain injury
Using cortical organoids, researchers discovered that targeting KCNJ2 could reduce nerve cell death after TBI.
news
Investigating new treatments for polycystic kidney disease
Organoid models enabled the researchers to study the effectiveness of eukaryotic ribosomal selective glycoside drugs on PKD cyst formation.
news
New link between FBXW7 mutations and EGFR signalling identified
The Organoid Group have discovered a link between FBXW7 mutations and the EGFR signalling pathway, which could improve colorectal cancer treatments.
article
Streamlining the path from lab to market with 3D bioprinting
In this Q&A, Dr Vidmantas Šakalys, CEO of Vital3D, provides insights into the potential of 3D bioprinting to revolutionise the traditional drug development process, facilitating more accurate models and limiting the use of animal testing.
webinar
Neurological disorders: organoids for early drug discovery
14 March 2024 | By Drug Target Review
Join us for this webinar as we explore the role of organoids in advancing treatment of neurological disorders. Organoids, miniature 3D models of human organs, are at the forefront of neuroscience research, offering insights into the complexities of the human brain. In this webinar, esteemed experts will explore the latest…
news
Brain organoids: essential ethical investigation
The potential for brain organoids to develop consciousness is a key issue in neuroscience, which has prompted new ethical considerations.
article
Colon cancer: distinct transcriptional programmes identified
Researchers elucidate the significant role of CDX2 in regulating stemness and differentiation, particularly in the proximal colon’s epithelial cells. This research encourages new combinations of existing drugs, that inhibit both the BRAF and KRAS genes, to be explored.
article
Modelling pregestational diabetes-induced congenital heart disease
Using an advanced human heart organoid system, researchers found the contributing factors to the condition and possible therapeutic compounds.
news
Organoid drug testing predicts bowel cancer treatment response
A new study proves that organoid drug testing is highly accurate at predicting effective treatments and finds a novel therapeutic option.
article
Mechanisms underlying pioneer TF-mediated gene repression
Researchers have made surprising and important findings that may influence organoid and cell reprogramming studies.
whitepaper
eBook: Modern Microscopy in Cancer Research
Explore the history and trends of microscopy in cancer research and discover the latest cancer imaging solutions and techniques in this eBook.
