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Improved CAR T-cell immunotherapy for acute myeloid leukaemia
Researchers have created dual-targeted CARs, which performed better than single-targeted CARs in both in vivo and in vitro experiments.
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Peptide Therapeutics
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Therapeutic peptide developed for triple-negative breast cancer
Scientists demonstrate how disrupting the Cx26 molecular complex in triple-negative breast cancer cells slowed tumour growth.
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Controlling MYC’s hyperactivity with a peptide compound
A novel peptide can suppress MYC by binding directly to it with sub-micro-molar affinity, advancing cancer drug development.
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Diagnosing inflammatory diseases with synthetic peptides
Researchers from Switzerland identify peptides that detect and measure a key biomarker in inflammatory conditions.
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New class of ribosomal peptide “daptides” discovered by researchers
Researchers from the University of Illinois have identified a new class of ribosomally synthesised and post-translationally modified peptides (RiPPs) named "daptides" that have haemolytic activity.
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Therapeutic approach prevents resistance to chemo in colon and rectal cancer
Scientist and doctors from Spain have uncovered that oxaliplatin, a chemotherapy drug used to treat colon and rectal cancer, avoids the side effects this treatment can have on normal tumour cells, including potential chemotherapy resistance
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Preventing diet-induced obesity in mice
Japanese researchers discover the mechanism of inhibition of diet-induced obesity in mice by the glucose-dependent insulinotropic polypeptide
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Novel peptide may tackle the root cause of type 2 diabetes
British researchers uncover peptide: PEPITEM that could reduce the risk of type 2 diabetes and other obesity-related conditions.
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Research reveals protein plaques associated with Alzheimer’s disease are stickier than thought
Scientists from Rice University are using fluorescence lifetime to shed new light on a peptide associated with Alzheimer’s disease.
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New study highlights lipid nanoparticles and mRNA could treat blindness
The researchers developed nanoparticles able to penetrate the neural retina and deliver mRNA to the photoreceptor cells whose proper function makes vision possible.
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A promising oral drug delivery platform could replace injections with pills
The researchers explored the possibility of using the probiotic bacteria Lactobacillus reuteri as a novel oral drug delivery platform to treat rheumatoid arthritis in an animal model.
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RNA therapeutics: the key to treat rare disease?
This exclusive interview highlights some of Dr Arthur Suckow’s insights into how his team uses RNA therapies to treat rare diseases such as Charcot-Marie-Tooth 1A.
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Peptides with anticancer potential discovered in new study
Researchers have found peptides that bind to chains of ubiquitin proteins in cancer cells, suggesting they could be used as a therapeutic strategy.
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Novel synthetic peptides could suppress formation of harmful amyloid aggregates
German researchers have designed peptides that bind to amyloidogenic proteins linked to Alzheimer’s and type 2 diabetes, to effectively suppress both cytotoxic amyloid aggregation and amyloid cross-accelerating interactions.
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Implant in mice most effective treatment for pancreatic cancer yet
A new implant that combines internal radiation and chemotherapy dissolved tumours in mice across multiple models.