A key receptor has been examined for the first time at high resolution which could lead to better treatments for conditions such as type 2 diabetes.
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A new technique has been developed which has the potential to harness bacteria to produce billions of different drug candidates to treat diseases like cancer.
A study has identified a protein complex elevated in PTSD patients and developed a peptide to disrupt it, preventing the recall of fear memories in early tests and paving the way for new therapies.
Unlike synthetic compound libraries, natural product hits must be identified and characterised, as the molecule is often unknown. Venom peptides are often inherently stable due to cysteine knots whereas other peptides may not be. Steve and Carol Trim discuss the challenges of the hit-to-lead journey with these non-standard hits.
A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
Researchers have developed a novel peptide with a prolonged half-life that has demonstrated success in rhesus monkeys and mice for inhibiting HIV infections.
A novel peptide has been discovered that attacks gram negative bacteria at a previously unknown site of action which presents a promising lead substance for the development of a new antibiotic.
The memory of mice with Alzheimer's greatly improved after they were injected with two newly discovered short peptides.
Scientists have shown that there are molecules to remodel the gut microbiome and turn an unhealthful gut into a more healthful one for the first time.
Antimicrobial peptides were found to act against Gram-negative bacteria and certain fungi by working either together or by adding up their individual effects...
Venoms are continually being researched as potential chemicals for medicinal therapeutics to treat autoimmune diseases and diabetes...