Target Molecule

ZFP64 protein is key to deadly blood cancer MLL

3 December 2018 | By Drug Target Review

ZFP64, an inconspicuous MLL fusion protein was found to be neccessary for the production of MLL proteins, and could be targeted to inprove outcomes of MLL...

Application note: Enabling single-software multiple attribute methodology (MAM) for the assessment of biopharmaceutical product quality attributes

29 November 2018 | By Fan Zhang, Sean McCarthy, Zoe Zhang

Development and production of biopharmaceuticals is complex. Even minor impurities, or changes in attributes such as glycosylation or charge heterogeneity, can have a profound impact on the safety and efficacy of the final product. Traditionally, multiple analytical techniques have been required to assess the full range of biopharmaceutical product attributes.…

Application note: A complete next-generation sequencing workflow for circulating cell-free DNA isolation and analysis

29 November 2018 | By Thermo Fisher Scientfic

Circulating cell-free DNA (cfDNA) has been shown to have potential as a noninvasive substrate for the detection and monitoring of tumour cells. As circulating tumour DNA is often present at low frequencies within cfDNA, targeted sequencing is an optimal tool for mutation detection.

Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets

29 November 2018 | By Brian P. Dranka, George W. Rogers, Sarah E. Burroughs

Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...

New technique to simultaneously target fibroblasts while killing cancer cells

19 November 2018 | By Drug Target Review

Scientists have equipped a virus that kills carcinoma cells with a protein so it can also target and kill adjacent cells...

SERDs molecules could spur a new class of drugs for breast cancer

4 October 2018 | By Drug Target Review

Stevens researchers design and develop a new class of molecules for breast cancer therapy...

Sugar specific molecules show promising results for new allergy vaccine

27 September 2018 | By Drug Target Review

Using sugar molecules researchers have developed a new vaccine for hay fever that may reduce treatment times and increase the effectiveness of treatments...

Inhibiting NF-κB improves heart function in Duchenne muscular dystrophy

31 August 2018 | By Drug Target Review

Breakthrough research has uncovered an unexpected mechanism that underlies cardiomyopathy in DMD...

Potential drug to cure ciliopathies

30 August 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a potential treatment that will be a foundation for developing drugs for various genetic disorders...

Bio-Techne

New ligand binding site identified through computer simulations

30 July 2018 | By Drug Target Review

Many therapeutic compounds target GPCRs and so new ligand binding sites can help to design drugs more efficient at targeting GPCR...

CMPK2 inhibitor could lesson symptoms of common illnesses

27 July 2018 | By Drug Target Review

CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...

Derm-BOT compound relieves chronic pain

23 July 2018 | By Dr Zara Kassam (Drug Target Review)

A modified form of botulinum toxin gives long-lasting pain relief in mice without adverse effects...

HRI depletion may be effective in treating sickle cell disease

20 July 2018 | By Drug Target Review

A protein identified in the signalling pathway for haemoglobin production has been identified as a possible target to treat sickle cell disease (SCD)...

MicroRNA: a new target for breast cancer research?

19 July 2018 | By Drug Target Review

A study has identified microRNA as a possible candidate to be used as a drug target for breast cancer research...