Small molecule inducers of trained immunity found
Researchers screened over 2,000 small molecules and have now more than doubled the known compounds reported to induce trained immunity.
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Researchers screened over 2,000 small molecules and have now more than doubled the known compounds reported to induce trained immunity.
In an animal model, scientists have demonstrated that targeting Interleukin-10 during vaccine delivery enhances the vaccine’s ability to protect against infection.
PVP-037, identified through a small molecule screen, induces a more durable and broader immune response to vaccines.
This report provides insights into current research and future prospects from potential breakthroughs to global collaboration in pandemic preparedness.
The proof-of-concept study could lead to a cure for HIV that inactivates diverse strains across multiple cellular contexts.
A new study shows that changes in clonal dominance characterises T-cell memory against multiple COVID-19 variants following mRNA vaccinations.
The study's findings could be applied to the development of new vaccine and therapeutic strategies for influenza.
A new vaccine, based on a nanoliposome that promotes proteins to be displayed on its surface, results in potent vaccine efficacy.
As humanity faces an impending era of pandemics, global collaboration among governments, organisations and industry is critical. In this article, epidemiologist Dr Jay Varma explores the urgent need for researching and developing drugs to combat a range of epidemic-prone pathogens, and reflects on the increased risk of spillovers and the…
Tips and tricks for fully leveraging Advanced Flow Cytometry.
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In Columbus, Ohio, scientists have made significant strides in developing vaccines to combat leishmaniasis, a disfiguring skin disease, through animal studies.
St. Jude Children’s Research Hospital, in collaboration with ESR Limited, discovered that specific immune cells present in individuals months before a flu infection can better predict symptom development compared to current antibody-based methods.