Hidden influenza vulnerability found in human antibodies
17 May 2019 | By Drug Target Review
Scientists have discovered an unexpected weakness in the influenza virus protein.
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Vaccine
Squaring the circle – cancer vaccines
8 May 2019 | By Matthias Giese
By the 1890s William B. Coley had injected streptococcal organisms in patients with solid tumours (“Coley’s Toxins”) to activate the immune system. Coley (1862-1936) was an American bone surgeon and pioneer of cancer immunotherapy. He was convinced that post-surgical infections had helped patients to recover better from their cancer by…
Drug Target Review Issue 1 2019
14 March 2019 | By Drug Target Review
In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.
DNA anticancer vaccine targets tumour neoantigens
24 January 2019 | By Iqra Farooq (Drug Target Review)
A DNA vaccine developed through the use of unique tumour antigens could lead the way towards vaccinating people against cancer...
Producing vaccines without the use of chemicals
15 January 2019 | By Drug Target Review
Innovative new technology will use electron beams to produce inactivated vaccines quickly, reproducibly and without the use of chemicals...
Vaccine could combat opioid addiction and reduce deaths
14 December 2018 | By Drug Target Review
Researchers have developed a vaccine to combat the opioid epidemic and to prevent deaths, with possible applications of the vaccine in many areas...
Vaccine signatures point to a better understanding of infectious diseases
29 November 2018 | By Drug Target Review
Researchers have developed a comprehensive way to evaluate how immune responses of humanised mice measure up to actual humans...
Freeze-dried vaccine may help eradicate polio
27 November 2018 | By Drug Target Review
Researchers have developed a polio vaccine that doesn't require refrigeration, meaning it could someday be used all over the world...
Pre-clinical testing with in vitro model may streamline vaccine development
20 November 2018 | By Drug Target Review
A team of scientists have developed the first modelling system for testing age-specific human immune responses to vaccines -- outside the body...
Majority of HIV persistence during ART due to infected cell proliferation
20 November 2018 | By Drug Target Review
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure...
Scientists test new anti-PD-L1 cancer vaccine against melanoma
10 November 2018 | By Dr Zara Kassam (Drug Target Review)
An experimental cancer vaccine that boosts the immune system's ability to fight cancers could work in tandem with other cancer therapies to fight aggressive tumours, scientists have reported...
Novel DNA vaccine offers broad protection against Influenza-A H3N
19 October 2018 | By Dr Zara Kassam (Drug Target Review)
Researchers developed a novel DNA influenza vaccine based on four micro-consensus antigenic regions selected to represent the diversity of seasonal H3N2 viruses...
Lassa fever vaccine reveals new test for immunity
15 October 2018 | By Drug Target Review
A Lassa fever vaccine offers researchers a different way to test for protection, which could aid the development of more potent vaccines...
Vaccine offers complete protection against Ebola virus
11 October 2018 | By Drug Target Review
Researchers at The Wistar Institute have developed a DNA based vaccine that has offered compete protection against the Ebola virus in preclinical trials...
Researchers develop a potential tool for efficacious targeted cancer therapy
8 October 2018 | By Drug Target Review
Researchers have developed PeptiENV, a cancer vaccine platform, which can be used to improve the therapeutic efficacy of oncolytic enveloped viruses...
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