Label-free ultra-high-throughput screening by MALDI Mass Spectrometry

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15 December 2016


A new MALDI Time-of-flight (TOF) Mass Spectrometer, designed for ultra-fast label-free screening of biochemical assays was presented: The rapifleX MALDI PharmaPulse (MPP) monitors substrates and all products and results in reliable determination of IC50 values, avoiding false positives. Measurement times of about 12 minutes per 1536 MALDI sample plate allow for the first time the use of Mass Spectrometry for primary screens.

The first part of the webinar introduced MALDI-TOF Mass Spectrometry for ultra-high-throughput screening (uHTS) in Drug Discovery. The presentation provided an overview of the latest technical enhancements of MALDI Mass Spectrometry, which are the key enabler to employ MALDI-uHTS for large primary screens in Drug Discovery. Furthermore the workflow, including the preparation of 1536 MALDI sample plates with high-speed nanolitre liquid handling was discussed.

The second part of the webinar focused on assay development strategies using a new HTS software suite for MALDI Mass Spectrometry. The software empowers assay developer to accelerate label-free assay development. Furthermore the new HTS screening software was presented including data management and automation concepts.


Meike HamesterMeike Hamester – Director Small Molecule Pharma Business, Bruker

Dr. Meike Hamester studied chemistry at the University of Hamburg, Germany. She worked 18 years in the field of mass spectrometry at Thermo Fisher Scientific. Since 2012 Meike works for BRUKER.

Jens FuchserJens Fuchser – Product Manager MALDI TOF, Bruker

Dr. Jens Fuchser studied chemistry at the University of Göttingen, Germany. In 2000 Jens joined BRUKER  Germany to work in the field of mass spectrometry.


Bruker is a global technology leader delivering innovative, integrated analytical instrumentation for use in the Food Safety, Environmental analysis, Life Science, Pharmaceutical, Forensic and Clinical Research markets.

Bruker Daltonics, a division of the Bruker corporation, provides cutting edge mass spectrometry solutions which include MALDI-TOF, UHR-QTOF, Ion Traps, FTMS as well as LC and GC systems to solve the most demanding analytical questions presented to these markets today.

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3 responses to “Label-free ultra-high-throughput screening by MALDI Mass Spectrometry”

  1. Rui Rocha says:

    Interest in Label Free

  2. IpekBosgelmez says:

    Interested in “Label-free ultra-high-throughput screening by MALDI Mass Spectrometry”

  3. sabari kirishwaran says:

    Detailing sessions of brucker is undoubtedly impact diverse group of audience but such demos and detailing are not frequent in nature.

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