whitepaper

Poster: Positive allosteric modulators of GABAA

Selective and non-selective positive allosteric modulators were evaluated for their effects on GABAA α1β1γ2L and α1β2γ2L subtypes…

GABAA receptors are targets for drugs used for treatment of anxiety disorders.

Poster: Positive allosteric modulators of GABA<sub>A</sub>

Many of the drugs function as positive allosteric modulators (PAMs) of GABA, potentiating the inhibitory activities of the ligand and channels within the CNS. Although some PAMs are relatively non-selective, others have been reported to preferentially potentiate channels containing β2 subunits over those containing β1 subunits. In this study, we evaluated selective and non-selective PAMs, for their effects on HEK293 and CHO cells expressing GABAA α1β1γ2L and α1β2γ2L subtypes.

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