Regenerative medicine: enhance cell bioprocessing through cell-based combinatorial culture

Regenerative medicine has emerged as one of the major areas of modern medical therapy. Its primary objective is to restore or establish normal function through the regeneration or replacement of diseased cells, tissues or entire organs. There are a variety of methods and approaches by which this can be achieved. These techniques include cell and gene therapy, tissue engineering or regenerative drug therapy.

There have been a number of key innovations in the field of regenerative medicine. Allogeneic transplantation of bone marrow haematopoietic stem cells (HSCs) was the pioneering regenerative medicine therapy. It can be used both to replace blood stem cells and to reconstitute the full blood lineage spectrum. The therapy has stood the test of time and is established as a gold standard in healthcare for many haematological disorders, decades after its introduction into the realms of therapy. However, despite all the developments to date, there remains a number of serious limitations to allogeneic transplantation of bone marrow. One issue is a discrepancy between supply and demand. This is caused by a number of significant factors including a shortage of bone marrow donors, the cell volumes required per transplantation and a degree of uncertainty over whether existing stocks of frozen umbilical cord blood cells can meet current and future demand.

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