Researchers have developed a new technique called mim-tRNAseq to measure, map and analyse tRNAs in cells, providing insight into disease.
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Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.
A high-throughput screening assay for macrocyclic peptides with affinity to ubiquitin has been created by researchers.
Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
A proton therapy that targets cancer cells which are resistant to treatment has shown success, sparing surrounding healthy cells.
A team has shown that STING activation is a new molecular target in the fight against graft-versus-host disease (GVHD).
Researchers have developed a personalised medicine platform that could advance genomic medicine research for cancer.
Using a mouse model, researchers found that cancer progression led to fewer skeletal muscle ribosomes, likely explaining muscle wasting.
Disrupting the interaction between the MYC oncogene and its co-factor, host cell factor (HCF)–1, was sufficient to cause Burkitt’s lymphoma cells to self-destruct in vivo.
A team has developed a new way to discover peptide therapeutics that inhibit HDAC enzymes and be effective against cancer.
The discovery of an inflammatory pathway promoting brain ageing and cognitive decline could lead to new treatments for age-related conditions.
A better understanding of the role of four-stranded DNA (G-quadruplex) could enhance cancer therapeutics, said the developers of the probes.
New insights into the mechanisms of anti-OX40 antibodies could enable their therapeutic activity to be manipulated to treat different tumours.
Dr H. Michael Shepard, CEO and CSO of Enosi Life Sciences, discusses the similarities between cancer and autoimmune diseases, highlighting how this knowledge could be used to enhance treatments.
Researchers have discovered that in mice with cancers in the liver, immunotherapy and radiotherapy prevented T-cell death.