Researchers created their new method to analyse chromosomes in 3D, revealing how misconfigurations play a role in cancer.
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Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.
Researchers have found that colorectal cancer-associated fibroblasts can be altered using a gremlin 1-neutralising antibody or by overexpressing meflin.
Drs Sam Cooper and Michael Briskin of Phenomic AI, discuss how artificial intelligence (AI) is enabling them to target multi-cellular interactions, such as those in the tumour stroma, for drug development.
Researchers have discovered that Importin-11, a cell nucleus import protein, is required for colorectal cancer growth and may be a possible target for new therapies.
Researchers have found that PGE2, a signalling molecule involved in inflammation, promotes colorectal cancer progression through a microRNA and targeting that microRNA could have therapeutic potential.
We are on the precipice of realising the true potential of genomics studies. Following completion of the Human Genome Project six years ago, huge strides have been made in understanding how the genome works, shedding light on disease pathogenesis and forging therapeutic efforts. In this article, Pushpanathan Muthuirulan explains how…
A study has found that signals from interferons can be blocked, allowing the immune system to attack tumours which provides a potential target.
IGF-1 activated by p38 may be a therapeutic target
A CAR-T-based immunotherapy successfully kills tumours and prevents metastatic growth, in final preclinical tests before human trials...
Scientists in the United States have investigated the relationship between tumour suppressor, protein kinase C zeta (PKC zeta), and metastatic colorectal cancer.
Saint Louis University researchers have had success in an animal model in turning off the excruciating pain that often accompanies a colorectal cancer drug.
Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...
Scientists have described a new type of test that can detect genetic mutations in minute amounts of DNA...
A highly sensitive method that can detect even the earlier stages of colorectal cancer has been developed by researchers in Japan.