Using tumour organoids, researchers identified that overexpression of Engrailed-1 blocked genes associated with natural cell death.
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pancreatic ductal adenocarcinoma (PDA)
Using bioinformatics analyses, HK-CREs impact on cellular processes was studied, including their potential as housekeeping tumour suppressors.
Researchers have discovered that pancreatic cancer cells secrete IL-1β to suppress the immune system and suggest antibody treatments as a therapy for pancreatic ductal adenocarcinoma.