New model offers a unique method to study Parkinson’s disease
Mice with rod-specific VPS35 deletion demonstrate a pathology more similar to human Parkinson’s disease, compared to other mouse models.
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Mice with rod-specific VPS35 deletion demonstrate a pathology more similar to human Parkinson’s disease, compared to other mouse models.
The world’s first generation of human BBB organoids from hPSCs accurately replicated features of cerebral cavernous malformation.
A synthetic antibody selectively activates the Wnt signalling pathway and directs stem cells to differentiate into neurons.
The new study found T3s treatment exhibited neuroprotective effects in HFSD-fed mice by mitigating oxidative stress.
In this Q&A, Dr Nicholas Waters, Head of R&D at IRLAB, shares how three compounds, including IRLABs Mesdopetam and an experimental dopamine D3 receptor antagonist, could reverse features associated with the psychosis-like state of Parkinson’s disease.
A condensed version of the SMN2 gene could improve discovery of potential therapies for spinal muscular atrophy and other conditions.
Researchers have found that using protein-like polymers to inhibit the Keap1/Nrf2 PPI is a powerful therapeutic strategy.
A new project plans to elucidate the relationship between the glucosylceramidase beta gene and Parkinson’s disease.
A new learning-based framework enables patients and caregivers to predict the timing of any of the five clinical groups of AD development.
Researchers found that ANG in its mutated form slows stem cell differentiation, resulting in neurodevelopmental defects in adult nerve cells.
In vitro and in vivo experiments highlight the advantages of a new targeted spectroscopy system for many eye diseases.
Researchers have developed a new method to study protein clumps that occur in many difficult-to-treat diseases.
iPS-cell-derived microglia in brain organoids have enabled scientists to understand early brain development and microglia-associated disease.
Drugs that boost autophagy hold great promise in preventing and halting neurodegenerative disorders. By ramping up the cell’s waste disposal system, they stimulate the removal of the toxic proteins that are a hallmark of brain conditions such as Alzheimer’s disease and Parkinson’s disease. Now, scientists are harnessing the power of…
Scientists have identified a novel cell type that combines astrocytic characteristics with the machinery for synaptic transmission. This discovery resolves years of debate in the field.