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Cell & gene therapy

news

Gene therapy reduces hepatocellular carcinoma in mice

8 December 2023 | By Drug Target Review

Increasing microRNA-22 overexpression in a gene therapy approach treated HCC in mice, offering promise for its prevention and treatment.

news

An altered protein can combat the growth of leukaemia cells

6 December 2023 | By Drug Target Review

Discovery about the NPM1c variant could lead to new drugs targeting the cell growth of acute myeloid leukaemia.

whitepaper

Beyond the lab: RNA

6 December 2023 | By Drug Target Review

Download this exclusive content focusing on new RNA editing technology, the challenges and opportunities presented and the potential of RNA-based therapeutics.

news

The IKAROS protein is crucial for B cell development

5 December 2023 | By Drug Target Review

By mapping the genome, scientists have discovered how IKAROS enables differentiation of hematopoietic stem cells into B cells.

article

New technology optimises mesenchymal stem cell extraction

1 December 2023 | By Ellen Capon (Drug Target Review)

A continuous sorting technique of stem cells on a DLD microfluidic platform may greatly advance cell therapy.

news

New contamination-detection test to improve T-cell therapy

28 November 2023 | By Drug Target Review

Method to improve sterility assurance in biopharmaceutic manufacturing will lead to better patient outcomes.

news

Noncoding RNA could be a new target for acute myeloid leukaemia

23 November 2023 | By Drug Target Review

Discovery about the DNA of leukaemia cells suggests promising target for gene therapy in paediatric oncology.

news

Genetically engineered transplants avoid immune rejection

23 November 2023 | By Drug Target Review

Researchers have found a way to genetically modify stem cells so that cell and organ transplants are not rejected.

news

Promising strategy for glaucoma cell replacement therapy

20 November 2023 | By Drug Target Review

Changing blood stem cells into retinal ganglion cells that can migrate to the eye’s retina offers hope for cell replacement therapy.

news

Macrophage phenotype insights could improve immunotherapy

17 November 2023 | By Drug Target Review

A certain macrophage phenotype is more effective than another phenotype commonly used in cell therapy for infiltrating tumours.

whitepaper

Handbook: Advanced flow cytometry handbook

15 November 2023 | By Sartorius

Don’t miss out on the easier way to do flow cytometry. Learn how to bring speed, throughput, multiplexing and miniaturization, to your bench.

news

Rare genetic variant blocks common Alzheimer’s disease risk factor

14 November 2023 | By Drug Target Review

New understanding of “Christchurch mutation” in the APOE gene may lead to novel Alzheimer's disease treatments.

Assays for protein degradation therapeutics to accelerate undruggable proteome discoveries

article

Understanding intracellular processes improves LYTACs therapy

7 November 2023 | By Ellen Capon (Drug Target Review)

New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.

Obese man with fatty liver, 3D illustration. Conceptual image for non-alcoholic fatty liver disease

news

Potential new targets for chronic liver disease

6 November 2023 | By Drug Target Review

Fatty liver disease treatments may become more effective after identification and greater understanding of more drug targets.

news

Utilising CAAR T cells to treat antibody-caused brain disease

6 November 2023 | By Drug Target Review

Researchers have engineered CAAR T cells to destroy harmful antibodies, improving NMDA receptor encephalitis treatment.

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Cell & gene therapy