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Crystal structure of the dopamine 2 receptor bound to an antipsychotic drug provides a much-needed discovery in the quest to create effective drugs with fewer side effects...
Reasons for phenotypic vs. target based drug discovery strategies, challenges of and maximising return of phenotypic assays.
Scientists have revealed the atomic-level structure of a molecular complex responsible for modifying proteins, paving the way for the development of new medications...
Water immersion lenses provide: brighter images from HCS samples; faster and gentler imaging; higher quality images from both 2D and 3D samples.
Researchers have developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognise and kill cancer cells.
A new report reveals the inner workings of fat tissue in mice and identifies potential targets for new drugs to treat and prevent obesity and diabetes...
Scientists at The Scripps Research Institute (TSRI) have discovered the workings of the first promising treatment for Marburg virus, a pathogen with the same pandemic potential as Ebola virus.
Researchers at the University of Louisville, Kentucky, have demonstrated that a new radiotracer, 2-18F-fluorodeoxysorbitol (18F-FDS), can identify and track bacterial infection in lungs better than current imaging methods and is able to differentiate bacterial infection from inflammation.
Researchers at Osaka University in Japan have developed a superior acid-tolerant green fluorescent protein to enhance the study of intracellular molecular dynamics.
In a proof-of-principle case report, researchers announce that targeted fluorescence successfully identified pulmonary metastases in a patient with osteosarcoma...
New technology may one day allow doctors to image therapeutic bacterial cells in patients...
Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...
A simple, non-invasive procedure that can indicate how long patients with cancer that has spread to the brain might survive and whether they are likely to respond to immunotherapy has been developed...
Scientists have created an injectable dye that illuminates molecules with near-infrared light...
While attempting to position two chips on a microscope, an involuntary exhalation by scientist Greg Madejski caused them to adhere to great effect.
