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Rare genetic variant blocks common Alzheimer’s disease risk factor
New understanding of “Christchurch mutation” in the APOE gene may lead to novel Alzheimer's disease treatments.
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Breaking new ground in endometriosis treatment
Endometriosis is a debilitating condition that affects millions of women worldwide, causing chronic pain, infertility, and a host of other distressing symptoms. Current treatments offer limited relief, but they do not address the cause of the disease. Professor Hugo Vankelecom, at the helm of the CurE-me project, is on a…
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Foxp3 protein governs regulatory T cell genome structure
Foxp3 alters chromatin architecture of regulatory T cells, meaning Foxp3 could become a target for therapies that modulate immunosuppression.
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Cancer and the DNA fork reversal mechanism
Researchers find that polymerase epsilon exonuclease is an essential target for cancer diagnosis and treatments that rely on DNA damage.
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Essential role of Nrg1 in heart development
New research identifies how trabeculae transform into ventricles, which could positively impact heart disease treatments.
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New bacterial protein found to improve mitochondrial function
Protein released by C. burnetti interacts with antioxidising enzyme GPX4 to prevent cell damage and death.
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Potential for improved rheumatoid arthritis treatment
Six types of inflammation with various cell types and disease pathways identified may provide better treatment of rheumatoid arthritis.
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How a dynein subunit maintains neuronal health
Understanding how a molecular transport system inside neurons works could be used for therapeutic approaches to neurodegenerative disease.
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Huntington’s disease: danger of repeated DNA sequences
Scientists find a way to slow the progression of Huntington’s disease by analysing DNA and find the basis of a potential treatment.
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New technique to extract and analyse extracellular vesicles
Cellulose nanofiber sheets enable analysis of EVs, and miRNAs within them, offering potential for cancer treatment and personalised medicine.
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Navigating the challenges of cell therapies
Cell therapies hold great potential for treating complex diseases, yet they face significant limitations and challenges. Current cell therapies have difficulty distinguishing between healthy and cancerous cells, often resulting in adverse effects. Vittoria's innovative Senza5 platform, with its unique CD5-targeting approach, aims to enhance the efficacy, safety, and speed of…
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Limiting diaphragm atrophy in intensive care
Mitochondrial fragmentation mechanism that can cause ventilator-induced diaphragm dysfunction (VIDD) found, and a therapeutic to mitigate it.
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Understanding intracellular processes improves LYTACs therapy
New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.
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DNA epigenetic changes: a key cause of cancer
Analysis of cells shows many regions in DNA are differentially activated or inactivated in a cancer-specific manner.
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Potential new targets for chronic liver disease
Fatty liver disease treatments may become more effective after identification and greater understanding of more drug targets.
