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Centre for Genomic Regulation

Allosteric control sites in KRAS protein found

5 January 2024 | By Ellen Capon (Drug Target Review)

The first complete control map for any protein has been made for KRAS, and four potential drug targets have been discovered.

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Source of nucleic-acid asymmetry could improve gene therapies

2 July 2019 | By Victoria Rees (Drug Target Review)

Researchers have analysed the physical origin and biological consequences of DNA-RNA hybrids which could inform gene therapies.

news

Chemical tags make differences in cell fate and gene expression

18 January 2019 | By Iqra Farooq (Drug Target Review)

Scientists from Spain have identified the specific roles of chemical tags in mammalian development and cancer in controlling genes...

news

Discovery of statistical method identifies cancer predisposition

12 July 2018 | By Drug Target Review

New statistical method, ALFRED, could identify predisposition for cancers by using cancer genome data sets to identify risk variants.

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Centre for Genomic Regulation

Allosteric control sites in KRAS protein found

Source of nucleic-acid asymmetry could improve gene therapies

Chemical tags make differences in cell fate and gene expression

Discovery of statistical method identifies cancer predisposition