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HIF inhibition: a potential therapeutic approach for cancers
In this Q&A, Curve Therapeutic’s Chief Scientific Officer Professor Ali Tavassoli discusses how dual HIF inhibition could combat solid tumours.
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Computational techniques
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Using omic data to develop and validate biomarkers of ageing
Researchers highlight the need for considering biomarkers alongside other health outcomes, as well as the need for omic data standardisation.
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Improved CAR T-cell immunotherapy for acute myeloid leukaemia
Researchers have created dual-targeted CARs, which performed better than single-targeted CARs in both in vivo and in vitro experiments.
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Mapping functional states of oncoproteins with AI
Researchers have developed a computational analysis tool which will improve patient stratification and enable personalised medicine.
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Blood test developed that reliably detects NEPC
A new blood panel test reports the tumour fraction and the tumour type of prostate cancer with a high level of accuracy.
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Novel computational model to study cancer dynamics
An advanced computational model enables scientists to study how cancer cells navigate through blood vessels.
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Potential of small molecule therapeutics for Barth syndrome
Novel findings about the tafazzin gene offers a potential new target and drug candidate for Barth syndrome.
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DNA epigenetic changes: a key cause of cancer
Analysis of cells shows many regions in DNA are differentially activated or inactivated in a cancer-specific manner.
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Spectra: new insights to improve immunotherapy treatments
New open-source computational method called Spectra improves analysis of single-cell transcriptomic data.
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Scientists discover extensive array of protein folds unexplored in nature
A study out of Japan reveals diversity of protein structures and how they fold in nature, uncovering a myriad of protein topologies.