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Cas12a enzyme could make CRISPR gene-editing more effective
Scientists have identified an easy upgrade for the technology that would lead to more accurate gene editing...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Potential peptide drug could treat liver cancer effectively
Researchers have discovered that FFW and Sorafenib used together could reduce the growth of Sorafenib resistant hepatocellular carcinoma tumours...
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D-PDMP reverses hair loss and skin damage linked to fatty diet
In a series of experiments, researchers have used an experimental compound to successfully reverse hair loss, hair whitening and skin inflammation...
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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AI system designs drugs from scratch
An artificial-intelligence approach created can teach itself to design new drug molecules from scratch and has the potential to dramatically accelerate the design of new drug candidates...
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CBD improves survival rates of mice with pancreatic cancer
Mice with pancreatic cancer that were treated with CBD alongside chemotherapy, survived almost three times longer than those treated with chemotherapy alone...
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CMPK2 inhibitor could lesson symptoms of common illnesses
CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...
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BCX7353 shows hope for hereditary angioedema
A new drug has been developed to help prevent attacks of hereditary angioedema and at the same offer patients a convenient administration...
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Researchers identify new arthritis severity gene
A new gene associated with disease severity in models of rheumatoid arthritis has been identified by...
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Promising drug targets for t-cell lymphoblastic leukaemia
Silencing the gene behind the production of HSP90, a target in the HSF1 pathway, effectively kills leukaemia cells, without affecting healthy cells...
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Curcumin eye drops may treat glaucoma
A derivative of turmeric could be used in eye drops to treat the early stages of glaucoma...
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Derm-BOT compound relieves chronic pain
A modified form of botulinum toxin gives long-lasting pain relief in mice without adverse effects...
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Bacterial outer membranes may be key to new antibiotics
The outer membrane surrounding the cell wall of bacteria may be a key target for approaches to a new form of antibacterial drugs...
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Cancer drug screening: the historical perspective
Chemotherapy with cytotoxic and growth inhibitory drugs have played an important role in cancer therapy, used either alone or in combination with other treatment modalities such as surgery, radiation or biological therapy. Chemotherapy, in most instances, was the only alternative treatment for metastatic cancer – mainly given as drug combinations...
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Revolutionary eye drops to treat age-related macular degeneration
Scientists are one step closer to developing an eye drop that could revolutionise treatment for age-related macular degeneration (AMD)...
