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New study reveals new drug target for gout & inflammatory diseases
Research reveals cathepsins as potential therapeutic targets in particulate-mediated inflammatory disease…
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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New drug targets identified to defend against chlamydia infections using CRISPR and stem cells
Human induced pluripotent stem cell derived macrophages (iPSDMs) provide a cell-based model system to study chlamydia infection in the laboratory. Amy Yeung from Wellcome Trust Sanger Institute explains how she used this model in combination with CRISPR-Cas 9 technology to explore the potential of the two genes, IRF5 and IL10RA,…
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Collaboration uses novel approach to identify antibacterial drug targets
LifeArc, the UK medical research charity previously known as MRC Technology; The Centre for Drug Research and Development (CDRD); and the Defence Science and Technology Laboratory (Dstl), have announced a collaboration to identify antibacterial drug targets.
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Scientists identify single-gene mutations that lead to eczema
NIH-supported research suggests potential treatment strategy following the identification of single-gene mutations that lead to eczema.
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Numab and Kaken enter into an antibody collaboration
Numab Therapeutics announced a collaboration and option agreement with Kaken Pharmaceutical for the identification of a multispecific antibody candidate for development in inflammatory disease.
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Newly discovered disease mechanism for type 2 diabetes
A newly discovered mechanism behind reduced insulin production in type 2 diabetes is now being presented.
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Drug Target Review – Issue #2 2017
Included in this issue: Technology convergence improves testing; Screening; Stem Cells; Targets; Mass Spectrometry; and Therapeutics in Alzheimer's disease...
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Optibrium, Imperial College and DNDi to collaborate on drug development
The collaboration will provide MSc students with industry-relevant learning tools and pharma with a new pipeline of candidate compounds.
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Making biological drugs with spider silk protein
Researchers at the Karolinska Institutet in Sweden have managed to synthesise lung surfactant, a drug used in the care of preterm babies, by mimicking the production of spider silk.
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Scientists to test Zika virus on brain tumours
The research, using tumour cells in the laboratory and in mice, will see if the Zika virus can destroy cancer cells.
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New targeted approach for epilepsy drug therapies
New research from the University of Liverpool, in collaboration with the Mario Negri Institute in Milan, has identified a protein that could help patients with epilepsy respond more positively to drug therapies.
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Exscientia to collaborate with Sanofi for EUR250mil multiple-product development
Exscientia has agreed a strategic research collaboration, and licence option agreement with Sanofi in the high-interest area of metabolic disease.
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Oxford Genetics licenses CRISPR technology for biotherapeutic discovery
Licensing agreement will expand Oxford Genetics growing bio-therapeutic discovery, design and development service business.
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New chlamydia drug targets discovered using CRISPR and stem cells
Scientists have created an innovative technique for studying how chlamydia interacts with the human immune system...
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Researchers identify potential Zika Virus target
New research provides insights into why infection with Zika virus after birth generally causes only mild symptoms, whereas devastating foetal malformations can develop when infection occurs during pregnancy.
