The mechanism of PARP inhibitor action is identified
New findings will enable the development of safer PARP inhibitors that inhibit PARP’s enzymatic activity without trapping it on DNA.
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Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
New findings will enable the development of safer PARP inhibitors that inhibit PARP’s enzymatic activity without trapping it on DNA.
Inhibiting the LDHA and GOT1 enzymes could prevent cancer cells’ ability to produce energy, without affecting healthy cells.
Treatment with Palbociclib and a compound targeting CAD increased survival to 100 percent for selected lymphoma cell lines.
Scientists have discovered that increasing the levels of the CDKL2 enzyme could stop CDD symptoms developing or worsening.
A mechanism by which the immune system influences central nervous system function and behaviour has been discovered.
Researchers discover a key metabolic process that cancer cells use to grow in a nutrient deprived environment, which could be a new target.
New understanding of the communication system between pathogens and host cells provides a way to avoid antimicrobial resistance.
A discovery about Zika’s enzyme, NS2B-NS3, offers promise for therapeutic targets for Zika and other flaviviruses.
Astrocyte plasticity is correlated with upregulation of the Galectin 3 protein, which may greatly contribute to biomarker discovery.
Researchers found heightened SCAN enzyme activity in humans and mice with diabetes results in excessive nitric oxide on insulin receptors.
Novel findings about the tafazzin gene offers a potential new target and drug candidate for Barth syndrome.
Advancements in enzyme-activated near-infrared fluorescent probes hold promise for evaluating responses to enzyme-targeting therapies.
Researchers find that polymerase epsilon exonuclease is an essential target for cancer diagnosis and treatments that rely on DNA damage.
HGPS mouse models were used to test the hypothesis that the accelerated aging typical of progeroid mice is associated with reduced hepatic H2S production.
US research reveals mechanism used by bacterial cells to repair their faulty DNA, which could help scientists understand the intricacies of DNA repair processes.