The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
List view / Grid view
Filter the results
Researchers have reported finding on an epigenetic signature in patient cells that appears to predict inflammation risk in Crohn's disease...
Researchers in the U.S. have identified a new link between epigenetic changes in the brains of rats and resulting translational control during fear memory reconsolidation.
Congestive heart failure is a terminal disease that affects nearly 6 million people in the U.S.; yet its management is limited to symptomatic treatments as its causal mechanisms – including its most common form, ischemic cardiomyopathy – are unknown.
A new system, pGENMi, could predict genomic features associated with drug responses, by identifying differences in gene expression...
Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone.
Progress in stem cell research and its translation to medicine is the focus of the International Society for Stem Cell Research annual meeting 20-23 June at the Melbourne Convention & Exhibition Centre in Melbourne, Australia.
A team of researchers in Spain show for the first time the complete epigenome of chronic lymphocytic leukaemia, the most common type of leukaemia.
Using data from multiple molecular databases, researchers from the University of Pennsylvania have found nine distinct types of exhausted T cells (‘Tex’), which could have implications for fighting chronic infections, autoimmunity, and cancer.
Epigenomic analyses may lead to other unexpected findings and novel therapeutic drug targets for many diseases
Researchers have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 protects mice and rats from noise- or drug-induced hearing loss...
A team of researchers from the have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease...