Breast cancer genetic variants in women of African ancestry
Researchers identified variants in three loci that were associated with risk of triple-negative breast cancer.
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Researchers identified variants in three loci that were associated with risk of triple-negative breast cancer.
Researchers uncover a genetic pathway of parietal cell development, which will enable a better understanding of stomach conditions.
Researchers have revealed that genetically enhanced expression of GSDMB causes a disturbed interferon-response.
The study’s findings explain the genetic differences in people’s blood pressure, which could lead to personalised medicine approaches.
Four previously unknown genetic variants provide a new understanding of differences in risk between individuals of varying ancestries.
Researchers have identified that gestational diabetes is associated with a deficit in placental expression of IGFBP1.
The discovery that genomic deletions cause altBRAFs can help develop new therapies to overcome drug resistance in BRAF-mutant melanoma.
In this Q&A, Associate Professor Dr Mete Civelek shares insights from the University of Virginia’s exciting recent study identifying several potential therapeutic targets for accelerating translational research in cardiovascular disease treatment, with a focus on proteins associated with the extracellular matrix (ECM) secretion by smooth muscle cells (SMCs).
Organoid models enabled the researchers to study the effectiveness of eukaryotic ribosomal selective glycoside drugs on PKD cyst formation.
The discovery that one missing copy of MUTYH could increase the risk of cancers may lead to therapeutics against solid tumours.
Mutation in two copies of the IKBKB gene leads to abnormal function of regulatory T cells, causing psoriatic arthritis.
New findings about how long genes become less active with age could impact treatments for neurodegeneration, among other conditions.
Using in situ sequencing, a collaborative research group analysed 260 genes and discovered new sub-structures in MS lesions.
The findings from DNA and RNA sequencing in primary and metastatic UTUC tumours could lead to strategies to improve patient outcomes.
In this Q&A, Dr Murray Cairns, NHMRC Leadership Research Fellow at the University of Newcastle, shares his insights about the genetic influences on circulating retinol, and explains how a retinol polygenic score could be utilised in a precision medicine approach.